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Comparative study on intermittent versus continuous use of a contraceptive pill administered by vaginal route.
There was a statistically significant difference in pregnancy rate between the two groups and there were no other significant differences in discontinuation rates despite marked differences in bleeding patterns, amenorrhea predominating in the continuous use group. Expand
Differences in serum potassium concentrations in normal men in different geographic locations.
There are regional differences in average serum [K+], with men in China having lower serum [ K+] than men elsewhere, which may predispose them to hypokalemia. Expand
Multicenter clinical trial on the efficacy and acceptability of a single contraceptive implant of nomegestrol acetate, Uniplant.
Results from this study confirm that Uniplant is an efficient, well tolerated, 12-month contraceptive implant, with the advantage of easier insertion and removal of the single implant compared to other multiple implant methods. Expand
Low dose gossypol for male contraception.
A regimen with 10 or 12.5 mg of gossypol as the daily loading dose and 35 or 43.75 mg as the weekly maintenance dose could induce infertility in male volunteers without developing hypokalemia or irreversibility. Expand
Segetoside F a new triterpenoid saponin with inhibition of luteal cell from the seeds of Vaccaria segetalis
Abstract A new triterpenoid saponin, named segetoside F, showing strong inhibition of luteal cell activity, has been isolated from the seeds of Vaccaria segetalis. Its structure has been established… Expand
Studies on gossypol. I. Toxicity, antifertility, and endocrine analyses in male rats.
Infertility occurred at all dose levels, but mating behavior was maintained throughout the period of treatment, and animals receiving 7.5 and 15 mg/kg/d of gossypol evidenced complete recovery of fertility. Expand
Chemical Constituents of Pteris multifida and Their Inhibitory Effects on Growth of Rat Prostatic Epithelial Cells in vitro
AIM: To study the active chemical constituents of Pteris multifida against growth of rat prostatic epithelial cells (PECs). METHODS: Column chromatographies of macroporous resin D-1400, Sephadex… Expand
Serum potassium: values in normal men in Shanghai vs those in men from Shanghai living abroad.
Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive. A multicenter, international, dose-finding study.
Gossypol blood levels indicated that sperm suppression occurs independently of concentration, whereas spermatogenesis recovery appears to be concentration-dependent, which may help this compound become a medical alternative to surgical vasectomy when the delay in onset of infertility is acceptable. Expand
Apoptosis induced by droloxifene and c-myc, bax and bcl-2 mRNA expression in cultured luteal cells of rats.
The results suggested that droloxifene could induce apoptosis of luteal cells of rat in vitro and the increase of c-myc mRNA expression might be one of the initiating factors and the elevated ratio of bax/bcl-2 mRNA was also probably involved in this effect. Expand