translesion synthesis

Known as: bypass DNA synthesis 
The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1982-2017
020406019822017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
The development of cancer drug resistance is a persistent clinical problem limiting the successful treatment of disseminated… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2010
2010
DNA polymerase eta is a Y family polymerase involved in translesion synthesis (TLS). Its action is initiated by simultaneous… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Translesion synthesis (TLS) is a potentially mutagenic method of bypassing DNA damage encountered during replication that… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2006
2006
Eukaryotic cells possess several mechanisms to protect the integrity of their DNA against damage. These include cell-cycle… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Translesion synthesis (TLS) is the major pathway by which mammalian cells replicate across DNA lesions. Upon DNA damage… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
In response to DNA damage, the Rad6/Rad18 ubiquitin-conjugating complex monoubiquitinates the replication clamp proliferating… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Stalled replication forks pose a serious threat to genome integrity. To overcome the catastrophic consequences associated with… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Most types of DNA damage block replication fork progression during DNA synthesis because replicative DNA polymerases are unable… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Cells have evolved checkpoint responses to arrest or delay the cell cycle, activate DNA repair networks, or induce apoptosis… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta (pol eta), which is involved in the replication of… (More)
Is this relevant?