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topsentin

 
National Institutes of Health

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2 relations

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ImidazolesIndoles

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2013
2013
A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin
A series of substituted ethyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-5-(1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl… Expand
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2013
2013
4-Amino-2-arylamino-5-indoloyl/cinnamoythiazoles, analogs of topsentin-class of marine alkaloids, induce apoptosis in HeLa cells.
Marine organisms provide several biologically active compounds that include alkaloids with high cytotoxic activity but only a few… Expand
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2013
2013
The bis(indolyl)imidazole alkaloid nortopsentin a exhibits antiplasmodial activity.
A library of enriched marine natural product fractions was screened for their antiplasmodial activity using a SYBR green I… Expand
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2007
2007
Bisindole alkaloids of the topsentin and hamacanthin classes from a marine sponge Spongosorites sp.
Seven new (1 and 3-8) and seven known (2 and 9-14) bisindole alkaloids of the topsentin and hamacanthin classes were isolated… Expand
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2007
2007
Total synthesis of marine sponge bis(indole) alkaloids of the topsentin class.
The synthesis of four natural bis(indole) alkaloids of topsentin class 1 and 2 is described. Their bis(indole) alpha… Expand
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2006
2006
Antimicrobial activity and cytotoxicity of bis(indole) alkaloids from the sponge Spongosorites sp.
Bis(indole) alkaloids, of the topsentin class (1-4) and hamacanthin class (5-9), isolated from the marine sponge Spongosorites sp… Expand
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2005
2005
Bis(indole) alkaloids as sortase A inhibitors from the sponge Spongosorites sp.
A new bis(indole) alkaloid (9) of the hamacanthin class along with the previously reported compounds of the related structural… Expand
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2000
2000
New bisindole alkaloids of the topsentin and hamacanthin classes from the Mediterranean marine sponge Rhaphisia lacazei.
Chemical investigation of the Et(2)O extract of the marine sponge Rhaphisia lacazei resulted in the isolation of 13 pure… Expand
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1999
1999
New Bis(Indole) alkaloids of the topsentin class from the sponge spongosorites genitrix
Four bis(indole) alkaloids of the topsentin class, including two new brominated compounds (1 and 2), have been isolated from the… Expand
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1991
1991
Antitumor activity and biochemical effects of topsentin
Abstract Topsentin, a bis(indolyl)imidazole marine natural product, inhibited… Expand
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