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tonabersat

Known as: 6-acetyl-4-(3-chloro-4-fluorobenzoylamino)-3,4-dihydro-2,2-dimethyl-2H-benzo(b)pyran-3-ol, N-((3S,4S)-6-Acetyl-3-hydroxy-2,2-dimethylchroman-4-yl)-3-chloro-4-fluorobenzamide 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

BenzamidesBenzopyrans

Narrower (1)

SB 220453

Papers overview

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2017
2017
Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels
The cis benzopyran compound tonabersat (SB-220453) has previously been reported to inhibit connexin26 expression in the brain by… 
Review
2014
Review
2014
Tonabersat for migraine prophylaxis: a systematic review.
BACKGROUND Randomized clinical trials assessing the efficacy and tolerability of tonabersat compared with placebo as prophylaxis… 
Review
2009
Review
2009
Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX)
Highly Cited
2009
Highly Cited
2009
Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Study of the Cortical Spreading Depression Inhibiting Agent Tonabersat in Migraine Prophylaxis
Tonabersat is a novel putative migraine prophylactic agent with an unique stereospecific binding site in the brain. Tonabersat… 
Highly Cited
2009
Highly Cited
2009
Tonabersat Inhibits Trigeminal Ganglion Neuronal‐Satellite Glial Cell Signaling
Background.— Sensitization and activation of trigeminal neurons are implicated in the underlying pathology of migraine, acute… 
Highly Cited
2009
Highly Cited
2009
Tonabersat, a Gap-Junction Modulator: Efficacy and Safety in Two Randomized, Placebo-Controlled, Dose-Ranging Studies of Acute Migraineceph
Tonabersat is a novel benzopyran derivative that blocks the cortical spreading depression proposed to be associated with migraine… 
Highly Cited
2009
Highly Cited
2009
Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study
2009
2009
Efficacy and Safety of Tonabersat, a Gap-Junction Modulator, in the Acute Treatment of Migraine: A Double-Blind, Parallel-group, Randomized Study
The ability of tonabersat to relieve the symptoms of migraine attacks with or without aura was evaluated in a randomized, double… 
2001
2001
Diffusion-Weighted MRI Used to Detect in Vivo Modulation of Cortical Spreading Depression: Comparison of Sumatriptan and Tonabersat
Spreading cortical depolarization and depression of electroencephalographic activity (SD) may underlie the aura and spreading… 
2001
2001
Tonabersat (SB‐220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve‐induced neurovascular reflexes
The effects of tonabersat (SB‐220453) were evaluated on trigeminal nerve ganglion stimulation‐induced sensory‐autonomic… 
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