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tonabersat

Known as: 6-acetyl-4-(3-chloro-4-fluorobenzoylamino)-3,4-dihydro-2,2-dimethyl-2H-benzo(b)pyran-3-ol, N-((3S,4S)-6-Acetyl-3-hydroxy-2,2-dimethylchroman-4-yl)-3-chloro-4-fluorobenzamide 
 
National Institutes of Health

Papers overview

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2017
2017
The cis benzopyran compound tonabersat (SB-220453) has previously been reported to inhibit connexin26 expression in the brain by… Expand
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Review
2014
Review
2014
Migraine is a common, recurrent, and disabling primary headache disorder with a genetic component which affects up to 20% of the… Expand
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Highly Cited
2009
Highly Cited
2009
Background.— Sensitization and activation of trigeminal neurons are implicated in the underlying pathology of migraine, acute… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Migraine with aura is thought likely to be caused by cortical spreading depression (CSD). Tonabersat inhibits CSD, and… Expand
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Highly Cited
2009
Highly Cited
2009
Tonabersat is a novel putative migraine prophylactic agent with an unique stereospecific binding site in the brain. Tonabersat… Expand
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2009
2009
Tonabersat is a novel benzopyran derivative that blocks the cortical spreading depression proposed to be associated with migraine… Expand
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2009
2009
The ability of tonabersat to relieve the symptoms of migraine attacks with or without aura was evaluated in a randomized, double… Expand
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Highly Cited
2001
Highly Cited
2001
Migraine headache is proposed to be mediated by nitric oxide (NO). Suitable mechanisms for eliciting increases in brain NO… Expand
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2001
2001
The effects of tonabersat (SB‐220453) were evaluated on trigeminal nerve ganglion stimulation‐induced sensory‐autonomic… Expand
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2001
2001
Spreading cortical depolarization and depression of electroencephalographic activity (SD) may underlie the aura and spreading… Expand
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