tonabersat

Known as: 6-acetyl-4-(3-chloro-4-fluorobenzoylamino)-3,4-dihydro-2,2-dimethyl-2H-benzo(b)pyran-3-ol, N-((3S,4S)-6-Acetyl-3-hydroxy-2,2-dimethylchroman-4-yl)-3-chloro-4-fluorobenzamide 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
BACKGROUND Randomized clinical trials assessing the efficacy and tolerability of tonabersat compared with placebo as prophylaxis… (More)
  • table 1
  • table 2
  • table 3
  • figure 1
Is this relevant?
2010
2010
  • Ivan Garza
  • Current neurology and neuroscience reports
  • 2010
Headache research was very limited before the 1980s. Since then, a better understanding of migraine pathophysiology has gradually… (More)
Is this relevant?
2009
2009
BACKGROUND Migraine with aura is thought likely to be caused by cortical spreading depression (CSD). Tonabersat inhibits CSD, and… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • table 4
Is this relevant?
2009
2009
BACKGROUND Sensitization and activation of trigeminal neurons are implicated in the underlying pathology of migraine, acute… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2009
2009
Tonabersat is a novel putative migraine prophylactic agent with an unique stereospecific binding site in the brain. Tonabersat… (More)
  • figure 1
  • figure 2
  • table 1
Is this relevant?
2009
2009
The ability of tonabersat to relieve the symptoms of migraine attacks with or without aura was evaluated in a randomized, double… (More)
  • table 1
  • figure 1
  • table 2
  • table 3
  • table 4
Is this relevant?
2009
2009
Tonabersat is a novel benzopyran derivative that blocks the cortical spreading depression proposed to be associated with migraine… (More)
  • table 1
  • table 2
  • figure 1
  • table 4
  • table 5
Is this relevant?
2001
2001
1. The effects of tonabersat (SB-220453) were evaluated on trigeminal nerve ganglion stimulation-induced sensory-autonomic… (More)
Is this relevant?
2001
2001
Migraine headache is proposed to be mediated by nitric oxide (NO). Suitable mechanisms for eliciting increases in brain NO… (More)
Is this relevant?
2001
2001
Spreading cortical depolarization and depression of electroencephalographic activity (SD) may underlie the aura and spreading… (More)
Is this relevant?