tonabersat

Known as: 6-acetyl-4-(3-chloro-4-fluorobenzoylamino)-3,4-dihydro-2,2-dimethyl-2H-benzo(b)pyran-3-ol, N-((3S,4S)-6-Acetyl-3-hydroxy-2,2-dimethylchroman-4-yl)-3-chloro-4-fluorobenzamide 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

BenzamidesBenzopyrans

Narrower (1)

SB 220453

Papers overview

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Review
2014
Review
2014
Tonabersat for migraine prophylaxis: a systematic review.
BACKGROUND Randomized clinical trials assessing the efficacy and tolerability of tonabersat compared with placebo as prophylaxis… (More)
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2010
2010
Tonabersat: a cortical spreading depression inhibitor as potential pharmacologic prophylaxis in migraine with aura.
  • Ivan Garza
  • Current neurology and neuroscience reports
  • 2010
Headache research was very limited before the 1980s. Since then, a better understanding of migraine pathophysiology has gradually… (More)
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2009
2009
Effects of tonabersat on migraine with aura: a randomised, double-blind, placebo-controlled crossover study
BACKGROUND Migraine with aura is thought likely to be caused by cortical spreading depression (CSD). Tonabersat inhibits CSD, and… (More)
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2009
2009
Tonabersat inhibits trigeminal ganglion neuronal-satellite glial cell signaling.
BACKGROUND Sensitization and activation of trigeminal neurons are implicated in the underlying pathology of migraine, acute… (More)
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2009
2009
Randomized, double-blind, placebo-controlled, proof-of-concept study of the cortical spreading depression inhibiting agent tonabersat in migraine prophylaxis.
Tonabersat is a novel putative migraine prophylactic agent with an unique stereospecific binding site in the brain. Tonabersat… (More)
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2009
2009
Efficacy and safety of tonabersat, a gap-junction modulator, in the acute treatment of migraine: a double-blind, parallel-group, randomized study.
The ability of tonabersat to relieve the symptoms of migraine attacks with or without aura was evaluated in a randomized, double… (More)
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2009
2009
Tonabersat, a gap-junction modulator: efficacy and safety in two randomized, placebo-controlled, dose-ranging studies of acute migraine.
Tonabersat is a novel benzopyran derivative that blocks the cortical spreading depression proposed to be associated with migraine… (More)
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2001
2001
Tonabersat (SB-220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve-induced neurovascular reflexes.
1. The effects of tonabersat (SB-220453) were evaluated on trigeminal nerve ganglion stimulation-induced sensory-autonomic… (More)
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2001
2001
Cortical spreading depression produces increased cGMP levels in cortex and brain stem that is inhibited by tonabersat (SB-220453) but not sumatriptan
Migraine headache is proposed to be mediated by nitric oxide (NO). Suitable mechanisms for eliciting increases in brain NO… (More)
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2001
2001
Diffusion-weighted MRI used to detect in vivo modulation of cortical spreading depression: comparison of sumatriptan and tonabersat.
Spreading cortical depolarization and depression of electroencephalographic activity (SD) may underlie the aura and spreading… (More)
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