Skip to search formSkip to main contentSkip to account menu

timegadine

Known as: N-cyclohexyl-N'-(2-methyl-4-quinolinyl)-N''-2-thiazolylguanidine 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Guanidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1994
1994
Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles.
The syntheses, biological evaluations, and structure-activity relationships of a series of 4,5-bis-(4-methoxyphenyl)-2… 
1988
1988
A comparison of the effect of timegadine, levamisole, and D-penicillamine on human neutrophil metabolism of endogenous arachidonic acid and chemotaxis.
The effect of timegadine, a novel experimental antirheumatic drug, on human neutrophil (PMN) 5-lipoxygenase activity and… 
Highly Cited
1988
Highly Cited
1988
CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes in vitro.
The effects of (Z)-5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H- indole-1-carboxamide (CP-66,248), a new anti… 
1988
1988
Timegadine: more than a non-steroidal for the treatment of rheumatoid arthritis. A controlled, double-blind study.
Timegadine is a tri-substituted guanidine derivative which inhibits both arachidonate cyclo-oxygenase and lipoxygenase activity… 
Highly Cited
1987
Highly Cited
1987
The amplified chemiluminescence test to characterize antirheumatic drugs as oxygen radical scavengers.
1986
1986
Regulation of rat natural killing. II. Inhibition of cytolysis and activation by inhibitors of lipoxygenase: possible role of leukotrienes.
1984
1984
The protein binding of timegadine determined by equilibrium dialysis.
The protein binding of timegadine to albumin, serum, plasma and plasma enriched with the acute phase reactants alpha 1-acid… 
1983
1983
Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction.
1983
1983
The influence of food intake on the bioavailability of timegadine, a novel non-steroidal anti-inflammatory drug.
The effects of food ingestion on the absorption of timegadine, a recently synthesised non-steroidal anti-inflammatory drug, was… 
1981
1981
An unusual profile of activity of a new basic anti-inflammatory drug, timegadine
Timegadine (SR 1368,N-cyclohexyl-N″-4-(2-methylquinolyl)-N′-2-thiazolylguanidine) dose-dependently inhibited carrageenan… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)