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thiolactomycin

Known as: 2(5H)-Thiophenone, 4-hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-, (S-(E))- 
National Institutes of Health

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Broader (2)

Anti-Bacterial AgentsThiophenes

Papers overview

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2017
2017
The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase.
Following the in vivo investigation of thiotetronate assembly in Lentzea sp. and in S. thiolactonus NRRL 15439 (Havemann et al… 
2010
2010
3D-QSAR, molecular docking studies, and binding mode prediction of thiolactomycin analogs as mtFabH inhibitors
Mycobacterium tuberculosis β-ketoacyl-acyl carrier protein synthase III (mtFabH) has been identified as a novel target for… 
2009
2009
Slow Onset Inhibition of Bacterial β-Ketoacyl-acyl Carrier Protein Synthases by Thiolactomycin*
Thiolactomycin (TLM), a natural product thiolactone antibiotic produced by species of Nocardia and Streptomyces, is an inhibitor… 
2009
2009
Synthesis and biological activity of enantiomeric pairs of 5-(Alk-2-enyl)thiolactomycin and 5-[(E)-Cycloalk-2-enylidenemethyl]thiolactomycin congeners.
The title compounds were synthesized by the efficient route previously explored for the synthesis of enantiomeric pairs of… 
2004
2004
Type selective inhibition of microbial fatty acid synthases by thiolactomycin
The antibiotic, thiolactomycin, is known to selectively inhibit the Type II straight-chain fatty acid synthase (monofunctional… 
2003
2003
Biosynthetic origins of the natural product, thiolactomycin: a unique and selective inhibitor of type II dissociated fatty acid synthases.
Thiolactomycin (TLM), a natural product produced by both Nocardia and Streptomyces spp., is a potent and highly selective… 
Highly Cited
2003
Highly Cited
2003
The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII.
Malaria, a disease caused by protozoan parasites of the genus Plasmodium, is one of the most dangerous infectious diseases… 
2003
2003
β-Ketoacyl-acyl carrier protein synthase III from pea (Pisum sativum L.): properties, inhibition by a novel thiolactomycin analogue and isolation of a cDNA clone encoding the enzyme
Abstract. A β-ketoacyl-acyl carrier protein (ACP) synthase III (KAS III; short-chain condensing enzyme) has been partly purified… 
1990
1990
Evidence for an acetoxyarylamine as the ultimate mutagenic reactive intermediate of the carcinogenic aromatic amine 2,4-diaminotoluene.
1986
1986
Inhibition of acetyl-coenzyme A dependent activation of N-hydroxyarylamines by phenolic compounds, pentachlorophenol and 1-nitro-2-naphthol.
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