thiocoraline
National Institutes of Health
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MbtH‐like proteins (MLPs) are required for soluble expression and/or optimal activity of some adenylation (A) domains of…
The natural compounds triostin and thiocoraline are potent antitumor agents that act as DNA bisintercalators. From a…
Medullary thyroid cancer (MTC) is an aggressive neuroendocrine tumor (NET). Previous research has shown that activation of Notch…
The ex vivo growth of implantable hepatic or cardiac tissue remains a challenge and novel approaches are highly sought after. We…
An antitumor agent thiocoraline is a thiodepsipeptide marine product derived from two Micromonospora sp. strains that inhibits…
Bridged N-methyl amides are used as isosteres for depsi and thiodepsi bonds in thiocoraline. The introduction of NMe-amides in…
Thiocoraline is a thiodepsipeptide antitumor agent that belongs to the family of bisintercalator natural products that bind…
The marine natural product thiocoraline A displayed approximately equal cytotoxic activity at nanomolar concentrations in a panel…
A modular method for assembling polyketide synthases accelerates the generation of new polyketides.