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tetrocarcin A

Known as: antlermicin A 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2018
01219802018

Related topics

Related topics

1 relation

Broader (1)

Aminoglycosides

Related mentions per year

Related mentions per year

1965-2018
1960198020002020
tetrocarcin A
Aminoglycosides

Papers overview

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2010
2010
Molecular architecture of a C-3'-methyltransferase involved in the biosynthesis of D-tetronitrose.
S-Adenosylmethionine (SAM)-dependent methyltransferases are involved in a myriad of biological processes, including signal… (More)
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2008
2008
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.
Tetrocarcin A (TCA), produced by Micromonospora chalcea NRRL 11289, is a spirotetronate antibiotic with potent antitumor activity… (More)
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2007
2007
Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers.
A survival kinase, Akt, is a downstream factor in the phosphatidylinositide-3'-kinase-dependent pathway, which mediates many… (More)
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2001
2001
Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions.
Tetrocarcin A was recently identified as an inhibitor of the anti-apoptotic function of Bcl-2. We synthesized novel tetrocarcin… (More)
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2000
2000
Tetrocarcin A inhibits mitochondrial functions of Bcl-2 and suppresses its anti-apoptotic activity.
Bcl-2 is an integral, intracellular membrane protein that prevents cells from undergoing apoptosis in response to a variety of… (More)
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2000
2000
Arisostatins A and B, new members of tetrocarcin class of antibiotics from Micromonospora sp. TP-A0316. II. Structure determination.
Structures of arisostatins A and B were determined by spectroscopic analyses. Arisostatins were found to be new analogs of… (More)
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1983
1983
Biosynthesis of tetrocarcin. Incorporation of 14C- and 13C-labeled compounds into tetrocarcin.
Micromonospora chalcea KY11091 produces tetrocarcin, showing antibacterial activity against Gram-positive bacteria and antitumor… (More)
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1982
1982
Tetrocarcins, new antitumor antibiotics. 3. Antitumor activity of tetrocarcin A.
Tetrocarcin A, isolated from a Micromonospora culture showed activity against experimental i.p. inoculated tumors such as Ehrlich… (More)
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1980
1980
Tetrocarcins, novel antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activity.
A novel antitumor antibiotic complex has been obtained from the culture broth of Actinomycete strain DO-11 (KY11091) isolated… (More)
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1980
1980
Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity.
Novel antitumor antibiotics, tetrocarcin complex composed of three components (A, B and C) were isolated from the culture broth… (More)
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