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tetrocarcin A

Known as: antlermicin A 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Aminoglycosides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Combined structural and functional investigation of a C-3''-ketoreductase involved in the biosynthesis of dTDP-L-digitoxose.
l-Digitoxose is an unusual dideoxysugar found attached to various pharmacologically active natural products, including the… Expand
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Highly Cited
2008
Highly Cited
2008
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.
Tetrocarcin A (TCA), produced by Micromonospora chalcea NRRL 11289, is a spirotetronate antibiotic with potent antitumor activity… Expand
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2007
2007
Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers.
A survival kinase, Akt, is a downstream factor in the phosphatidylinositide-3'-kinase-dependent pathway, which mediates many… Expand
2003
2003
Bcl-2阻害剤 Tetrocarcin Aによるヒト悪性黒色腫細胞のアポトーシス誘発とその機構
 
2001
2001
Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions.
Tetrocarcin A was recently identified as an inhibitor of the anti-apoptotic function of Bcl-2. We synthesized novel tetrocarcin… Expand
Highly Cited
2000
Highly Cited
2000
Tetrocarcin A inhibits mitochondrial functions of Bcl-2 and suppresses its anti-apoptotic activity.
Bcl-2 is an integral, intracellular membrane protein that prevents cells from undergoing apoptosis in response to a variety of… Expand
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2000
2000
Suppresses Its Anti-apoptotic Activity Tetrocarcin A Inhibits Mitochondrial Functions of Bcl-2 and Updated
Bcl-2 is an integral, intracellular membrane protein that prevents cells from undergoing apoptosis in response to a variety of… Expand
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1982
1982
Tetrocarcins, new antitumor antibiotics. 3. Antitumor activity of tetrocarcin A.
Tetrocarcin A, isolated from a Micromonospora culture showed activity against experimental i.p. inoculated tumors such as Ehrlich… Expand
Highly Cited
1980
Highly Cited
1980
Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity.
Novel antitumor antibiotics, tetrocarcin complex composed of three components (A, B and C) were isolated from the culture broth… Expand
1980
1980
Tetrocarcins, novel antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activity.
A novel antitumor antibiotic complex has been obtained from the culture broth of Actinomycete strain DO-11 (KY11091) isolated… Expand
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