tetra(4-N-methylpyridyl)porphine

Known as: 5,10,15,20-tetrakis(N-methylpyridinium-4-yl)-21H,23H-porphyrin, tetra-Py-Me, TMPyP4 
 
National Institutes of Health

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Broader (5)

Angiogenesis InhibitorsAnti-Infective AgentsEnzyme InhibitorsPhotosensitizing Agents
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Narrower (1)

tetra(4-N-methylpyridyl)porphine tetraperchlorate

Papers overview

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Highly Cited
2008
Highly Cited
2008
Genome-wide computational and expression analyses reveal G-quadruplex DNA motifs as conserved cis-regulatory elements in human and related species.
Using a combination of in silico and experimental approaches, we present evidence that the G-quadruplex (G4) motif (an… (More)
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Highly Cited
2007
Highly Cited
2007
Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4
The proximal 5'-flanking region of the human platelet-derived growth factor A (PDGF-A) promoter contains one nuclease… (More)
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Highly Cited
2006
Highly Cited
2006
G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription
In human and mouse, the promoter of the KRAS gene contains a nuclease hypersensitive polypurine-polypyrimidine element (NHPPE… (More)
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Highly Cited
2005
Highly Cited
2005
Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive…
The proximal promoter region of the human vascular endothelial growth factor (VEGF) gene contains a polypurine/polypyrimidine… (More)
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2005
2005
Photodynamic effect of the porphyrin derivative meso-tetra (4-N-methylpyridyl) porphine on sister chromatid exchanges in meristematic cells
The porphyrin derivative meso-tetra (4-N-methyl-pyridyl) porphine tetraiodide (TMpyP) was tested for its ability to induce sister… (More)
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Highly Cited
2005
Highly Cited
2005
Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter.
It has been widely accepted that DNA can adopt other biologically relevant structures beside the Watson-Crick double helix. One… (More)
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Highly Cited
2002
Highly Cited
2002
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex.
Telomestatin is a natural product isolated from Streptomyces anulatus 3533-SV4 and has been shown to be a very potent telomerase… (More)
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Highly Cited
2002
Highly Cited
2002
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription.
The nuclease hypersensitivity element III(1) upstream of the P1 promoter of c-MYC controls 85-90% of the transcriptional… (More)
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Highly Cited
2002
Highly Cited
2002
The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivo.
Cationic porphyrins are being studied as possible anticancer agents because of their ability to bind to and stabilize DNA guanine… (More)
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Highly Cited
2001
Highly Cited
2001
Selective interactions of cationic porphyrins with G-quadruplex structures.
G-quadruplex DNA presents a potential target for the design and development of novel anticancer drugs. Because G-quadruplex DNA… (More)
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