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telotristat etiprate

Known as: Ethyl 4-(2-amino-6-((1r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pryrimidin-4-yl)-l-phenylalaninate N-benzoylglycinate (1:1) 
An orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor prodrug, with potential antiserotonergic activity. Upon administration… 
National Institutes of Health

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LX1032LX1606

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telotristat

Papers overview

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Review
2018
Review
2018
Developments in the treatment of carcinoid syndrome – impact of telotristat
Carcinoid syndrome occurs in 20% of patients with neuroendocrine tumors, and serotonin is usually the main causative hormonal… 
2017
2017
Preparation of Benzyl((R)-2-(4-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)acetyl)-D-phenylalaninate using Umpolung Amide Synthesis
Benzyl ((R)-2-(4-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)amino)acetyl)D-phenylalaninate (2). A three-necked, 1-L round… 
Review
2016
Review
2016
Inhibition of Peripheral Synthesis of Serotonin as a New Target in Neuroendocrine Tumors.
UNLABELLED : The carcinoid syndrome represents a set of signs and symptoms associated with neuroendocrine tumors (NETs) that… 
2016
2016
Assessing treatment benefit of telotristat etiprate in patients with carcinoid syndrome: Patient exit interviews
Assessing Treatment Benefit of Telotristat Etiprate in Patients with Carcinoid Syndrome : Patient Exit Interviews 
2016
2016
New Developments in the Treatment of Neuroendocrine Tumours – RADIANT-4, NETTER-1 and Telotristat Etiprate
Abstract Neuroendocrine tumours (NETs) are a heterogeneous group of neoplasms whose incidence has increased significantly in… 
2016
2016
Efficacy and safety of telotristat etiprate in patients with carcinoid syndrome not adequately controlled by somatostatin analog therapy: Analysis of the ongoing TELESTAR extension period
Efficacy and Safety of Telotristat Etiprate in Patients with Carcinoid Syndrome Not Adequately Controlled by Somatostatin Analog… 
Review
2015
Review
2015
Telotristat etiprate, a novel inhibitor of serotonin synthesis for the treatment of carcinoid syndrome
Excessive serotonin secretion is the hallmark of carcinoid syndrome. It leads to diarrhea, cramping, abdominal pain, wheezing and… 
2015
2015
Inhibition of Neuroinflammation by Synthetic Androstene Derivatives Incorporating Amino Acid Methyl Esters on Activated BV‐2 Microglia
Androstene derivatives incorporating amino acid methyl esters were prepared, and their anti‐inflammatory effects were evaluated… 
Highly Cited
2014
Highly Cited
2014
Telotristat etiprate, a novel serotonin synthesis inhibitor, in patients with carcinoid syndrome and diarrhea not adequately controlled by octreotide.
Serotonin produced by neuroendocrine tumors is believed to be a principal cause of the diarrhea in carcinoid syndrome. We… 
1999
1999
A Novel, One-Pot Reductive Alkylation of Amines by S-Ethyl Thioesters Mediated by Triethylsilane and Sodium Triacetoxyborohydride in the Presence of Palladium on Carbon.
The reductive alkylation of primary amines with aldehydes or ketones is an important tool in the synthesis of wide variety of… 
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