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telapristone acetate

Known as: (8S,11R,13S,14S,17R)-11-(4-(Dimethylamino)phenyl)-17-(2-methoxyacetyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl Acetate 
The acetate form of the 21-substituted-19-nor-progestin telapristone, an orally available selective progesterone receptor modulator (SPRM), with… 
National Institutes of Health

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CDB 4124Proellex

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Abstract P6-21-12: Local transdermal therapy (LTT): Drug permeation and distribution of telapristone acetate (TPA) in a pre-surgical window study of women undergoing mastectomy
2018
2018
Abstract P5-14-01: Telapristone acetate abrogates PR-dependent paracrine-mediated mammary cell proliferation
Background: Blockade of the progesterone (P)-progesterone receptor (PR) axis is a novel but untested strategy for breast cancer… 
2018
2018
Abstract 1812: Mechanism of telapristone acetate (CDB4124) on progesterone receptor action in breast cancer cells
Progesterone is a steroid hormone that plays an important role in the breast. Progesterone exerts its action through binding to… 
2018
2018
Abstract P6-07-09: Attenuation of progesterone driven mammary stem cell expansion by telapristone acetate
Review
2017
Review
2017
A peek into the drug development scenario of endometriosis - A systematic review.
2017
2017
Abstract OT3-02-09: Phase II pre-surgical window trial of telapristone acetate (TPA) in early breast cancer and DCIS patients: Distribution of TPA in plasma, normal breast tissue and tumors
Background:In vitro and preclinical data support the notion that anti-progesterone therapy will have activity against both… 
2016
2016
Abstract P3-11-01: Telapristone acetate suppresses the expression of genes involved in cell proliferation, stem cell self-renewal, and anti-apoptosis in MNU-induced rat mammary tumors
Background: We previously reported that telapristone acetate (TPA), an anti-progestin, significantly suppressed mammary tumor… 
2010
2010
Abstract P4-02-07: A Progesterone Receptor Modulator, CDB-4124, Inhibits Mammary Carcinogenesis by Suppressing Cell Proliferation In Vitro and In Vivo
CDB-4124 (Proellex or Telapristone acetate) is a modulator of progesterone receptor (PR) signaling which has been employed in… 
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