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Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial
A 6-month intervention of mixed soy isoflavones in healthy, high-risk adult Western women did not reduce breast epithelial proliferation, suggesting a lack of efficacy for breast cancer prevention and a possible adverse effect in premenopausal women.
Oral low dose and topical tamoxifen for breast cancer prevention: modern approaches for an old drug
Findings suggest possible beneficial clinical preventive effects by low-dose tamoxifen regimens and they are supported by observational studies.
Dendron‐Based Micelles for Topical Delivery of Endoxifen: A Potential Chemo‐Preventive Medicine for Breast Cancer
The enhanced drug loading, controlled release profiles, and enhanced skin permeation all demonstrate that DMs are a useful platform for the topical delivery of EDX, offering a potential alternative administration route for chemoprevention.
The relationship of single-strand breaks in DNA to breast cancer risk and to tissue concentrations of oestrogens
- Mathavi Sahadevan, O. Lee, R. Chatterton
- MedicineBiomarkers : biochemical indicators of exposure…
- 28 February 2017
Quantitative measurement of SSBs by this procedure indicates the relative number of SSB and is related to promoter methylation, antioxidant availability and percent breast density.
Lipid Metabolism Genes in Contralateral Unaffected Breast and Estrogen Receptor Status of Breast Cancer
Data suggest that differential expression of lipid metabolism genes may be involved in the risk for subtypes of breast cancer, and are potential biomarkers of ER-specific breast cancer risk.
Local transdermal therapy to the breast for breast cancer prevention and DCIS therapy: preclinical and clinical evaluation
These results demonstrate that lipophilic drugs can be developed for LTT; although the nude rat is suitable for testing drug permeability, delivery is systemic.
Progesterone receptor antagonism inhibits progestogen-related carcinogenesis and suppresses tumor cell proliferation.
Abstract P5-14-01: Telapristone acetate abrogates PR-dependent paracrine-mediated mammary cell proliferation
It is demonstrated that TPA abrogates cell proliferation induced by exogenous EP hormones in an ovary intact mouse model and warrants further testing in a breast cancer prevention trial.
In vitro human skin permeation of endoxifen: potential for local transdermal therapy for primary prevention and carcinoma in situ of the breast.
The addition of OA to ENX results in a favorable rapid delivery equivalent to that of estradiol, a widely used transdermal hormone.
Mechanism of Telapristone Acetate (CDB4124) on Progesterone Receptor Action in Breast Cancer Cells.
- Batzaya Davaadelger, Alina R. Murphy, S. Clare, O. Lee, S. Khan, J. Kim
- 6 September 2018
Investigation of the molecular mechanism by which TPA antagonizes PR action demonstrates that treatment with the progestin (R5020) alone resulted in robust PR recruitment to the chromatin, and addition of TPA reduced PR recruitment globally.