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telaprevir

Known as: (1S,3AR,6as)-(2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-((1S)-1-((cyclopropylamino)oxoacetyl)butyl)octahydrocyclopenta(c)pyrrole-1-carboxamide 
An orally available peptidomimetic small molecule with activity against hepatitis C virus (HCV). Telaprivir is a selective protease inhibitor that… 
National Institutes of Health

Related topics

Related topics

7 relations
HCV NS3/4A Protease Inhibitors [MoA]Hepatitis C

Narrower (4)

IncivekLY-570310MP-424VX 950

Broader (1)

Oligopeptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Determination of the HCV Protease Inhibitor Telaprevir in Plasma and Dried Blood Spot by Liquid Chromatography–Tandem Mass Spectrometry
Background: Telaprevir is a protease inhibitor used in the treatment of hepatitis C virus infection. Analytical methods for… 
2014
2014
Prediction of Sustained Virological Response to Telaprevir-Based Triple Therapy Using Viral Response within 2 Weeks
The aim of the present study was to predict sustained virological response (SVR) to telaprevir with pegylated interferon (PEG-IFN… 
2013
2013
All-oral HCV therapies near approval
Gilead has filed the first interferon-free hepatitis C virus regimen for approval in the United States, but drug developers are… 
2013
2013
HCV treatment--no more room for interferonologists?
The landscape of therapy for hepatitis C virus (HCV) infection is changing rapidly. Until recently, the standard of care for HCV… 
2013
2013
Serious neuropsychiatric adverse effects in a hepatitis C virus/hepatitis B virus/HIV-coinfected patient receiving bosentan and telaprevir.
s of the Fifty-first Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, USA, 2011. Abstract 1738a… 
2012
2012
Boceprevir and Calcineurin inhibitors - Is there a role for treating Hepatitis C recurrence after liver transplantation?
Cirrhosis from Hepatitis C (HCV) remains the leading indication for liver transplantation in the United States with recurrent… 
2012
2012
Safety of Telaprevir for Chronic Hepatitis C Virus Infection A Meta-Analysis of Randomized Controlled Trials
Background: Previous studies have reported telaprevir is effective for chronic hepatitis C virus infection, but the safety of a… 
2011
2011
Hepatitis C — pipeline update
2010
2010
Excitement grows for potential revolution in hepatitis C virus treatment
Data from a late-stage trial of the most advanced of a new class of drugs targeting the hepatitis C virus protease fuel hopes for… 
2009
2009
Telaprevir for chronic HCV infection.
n engl j med 361;5 nejm.org july 30, 2009 533 Madrid AH, Bueno MG, Rebollo JM, et al. Use of irbesartan 1. to maintain sinus…