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tarextumab

A monoclonal antibody directed against the Notch receptor with potential antineoplastic activity. Tarextumab binds to Notch on the cell surface… Expand
National Institutes of Health

Papers overview

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2019
2019
PURPOSE Both EGFR and PI3K-Akt signaling pathways have been used as therapeutically actionable targets, but resistance is… Expand
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2018
2018
SummaryPurpose This Phase I trial evaluated the maximum tolerated dose, safety, pharmacokinetics, pharmacodynamics and… Expand
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2017
2017
Epidermal growth factor receptor (EGFR) blockade and radiation are efficacious in the treatment of cancer, but resistance is… Expand
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2017
2017
279Background: Tarextumab (TRXT), fully human IgG2 antibody inhibits signaling of Notch2/ 3 receptors. Tumor regression seen in… Expand
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2016
2016
8564Background: Notch signaling is implicated in cancer stem cell self-renewal and proliferation, thus it is an appealing target… Expand
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Highly Cited
2015
Highly Cited
2015
PURPOSE The Notch pathway plays an important role in both stem cell biology and cancer. Dysregulation of Notch signaling has been… Expand
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Review
2015
Review
2015
Over 100 years have passed since the first observation of the notched wing phenotype in Drosophila melanogaster, and significant… Expand
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2015
2015
7508 Background: Notch signaling is implicated in cancer stem cell self-renewal and proliferation; thus being an appealing target… Expand
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2015
2015
278 Background: Tarextumab (TRXT), fully human IgG2 antibody, inhibits signaling Notch 2, 3 receptors. Tumor regression seen in… Expand
Is this relevant?
2015
2015
The US Food and Drug Administration has granted orphan drug designation to tarextumab for the treatment of pancreatic cancer and… Expand
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