sterol regulatory element binding protein cleavage

Known as: SREBP cleavage, sterol depletion response, SREBP cleavage, sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway 
The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1968-2018
051019682018

Papers overview

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2012
2012
Sterol regulatory element binding proteins (SREBPs) are essential transcriptional factors that control expression of lipogenic… (More)
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2005
2005
In the process of membrane biogenesis several dozen proteins must operate in precise concert to generate approximately 100 lipids… (More)
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Highly Cited
2004
Highly Cited
2004
Insig-1 and Insig-2 are closely related proteins of the endoplasmic reticulum (ER) that block proteolytic activation of sterol… (More)
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Highly Cited
2002
Highly Cited
2002
This paper describes insig-2, a second protein of the endoplasmic reticulum that blocks the processing of sterol regulatory… (More)
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Highly Cited
2002
Highly Cited
2002
Using coimmunoprecipitation and tandem mass spectrometry, we identify INSIG-1 as an ER protein that binds the sterol-sensing… (More)
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Highly Cited
2001
Highly Cited
2001
In liver, the synthesis of cholesterol and fatty acids increases in response to cholesterol deprivation and insulin elevation… (More)
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1999
1999
We describe a line of mutant Chinese hamster ovary cells, designated SRD-13A, that cannot cleave sterol regulatory element… (More)
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Highly Cited
1998
Highly Cited
1998
Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in… (More)
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Highly Cited
1997
Highly Cited
1997
SREBP cleavage-activating protein (SCAP) stimulates the proteolytic cleavage of membrane-bound SREBPs, thereby initiating the… (More)
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Highly Cited
1996
Highly Cited
1996
Through expression cloning we have isolated a cDNA-encoding SREBP cleavage-activating protein (SCAP), which regulates cholesterol… (More)
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