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steroid hydroxylase activity

Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. [ISBN:0721662544]

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Topic mentions per year

1975-2006
02419752006

Papers overview

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Highly Cited
2001
Highly Cited
2001
Identification and functional characterization of eight CYP3A4 protein variants.
The genetic component of the inter-individual variability in CYP3A4 activity has been estimated to be between 60% and 90%, but… (More)
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2001
2001
Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity.
Phenylalanine and/or tryptophan scanning mutagenesis was performed at 15 sites within CYP3A4 proposed to be involved in substrate… (More)
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1999
1999
Cytochrome P450 and steroid hydroxylase activity in mouse olfactory and vomeronasal mucosa.
The aims of this study are to identify the sex steroid-metabolizing cytochrome P450 enzymes of the vomeronasal organ (VNO) and to… (More)
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1998
1998
Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation.
Sequence alignment of human cytochrome P450 3A4 with bacterial enzymes of known structure has provided a basis from which to… (More)
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1997
1997
Effects of the neem tree compounds azadirachtin, salannin, nimbin, and 6-desacetylnimbin on ecdysone 20-monooxygenase activity.
The effects of azadirachtin, salannin, nimbin, and 6-desacetylnimbin on ecdysone 20-monooxygenase (E-20-M) activity were examined… (More)
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1993
1993
Effects of plant flavonoids and other allelochemicals on insect cytochrome P-450 dependent steroid hydroxylase activity.
The plant flavonoids flavone, chrysin, apigenin, kaempferol, morin, quercetin, myricetin and phloretin were found to inhibit in a… (More)
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1993
1993
Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.
We have cloned a cDNA encoding mouse steroid 7 alpha-hydroxylase P450(7) alpha (cytochrome P-450(7) alpha) and expressed it in… (More)
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1992
1992
Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion.
The onset of the sexually dimorphic pattern of GH secretion and increased hepatic GH-binding capacity in rats at puberty is… (More)
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Highly Cited
1991
Highly Cited
1991
Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s.
Steroid hydroxylation specificities were determined for 11 forms of human cytochrome P450, representing four gene families and… (More)
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1977
1977
The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat.
The effects of delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on hydroxylation of estradiol and testosterone in rat… (More)
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