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splitomicin

National Institutes of Health

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2 relations

Broader (2)

NaphthalenesPyrones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Three‐Component Aminoalkylations Yielding Dihydronaphthoxazine‐Based Sirtuin Inhibitors: Scaffold Modification and Exploration of Space for Polar Side‐Chains
Nonpolar derivatives of heterocyclic aromatic screening hits like the non‐selective sirtuin inhibitor splitomicin tend to be… 
2014
2014
Studies on Chromene Derivatives
Chromans, chromenes and Dihydrocoumarins, are important classes of benzopyran derivatives found in many natural products and… 
2012
2012
Inhibition of SIRT 2 Potentiates the Anti-motility Activity of Taxanes : Implications for Antineoplastic Combination Therapies 1 , 2
Taxanes are potent inhibitors of cell motility, a property implicated in their antiangiogenic and antimetastatic activity and… 
2011
2011
Effect of resveratrol derivative BTM-0512 on high glucose-induced dysfunction of endothelial cells: role of SIRT1.
Hyperglycemia impairs the function of endothelial cells. Sirtuin 1 (SIRT1) is involved in regulating the function of endothelial… 
2011
2011
Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins).
2009
2009
Splitomicin suppresses human platelet aggregation via inhibition of cyclic AMP phosphodiesterase and intracellular Ca++ release.
2003
2003
[Functional analysis of SIR2].
The yeast silent information regulator 2 (Sir2) is an NAD-dependent histone deacetylase and silences transcription at the mating… 
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