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Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation
- Courtney M. Lappas, Y. Day, M. Marshall, V. Engelhard, J. Linden
- The Journal of experimental medicine
- 27 November 2006
Ischemia reperfusion injury results from tissue damage during ischemia and ongoing inflammation and injury during reperfusion. Liver reperfusion injury is reduced by lymphocyte depletion or… Expand
Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages.
- Y. Day, L. Huang, H. Ye, J. Linden, M. Okusa
- American journal of physiology. Renal physiology
- 1 April 2005
The role of monocytes/macrophages in the pathogenesis of ischemia-reperfusion injury (IRI) is unknown. We sought to determine whether activation of macrophage adenosine 2A (A(2A)) receptors (A(2A)Rs)… Expand
A Critical Role of the Adenosine A2A Receptor in Extrastriatal Neurons in Modulating Psychomotor Activity as Revealed by Opposite Phenotypes of Striatum and Forebrain A2A Receptor Knock-Outs
- Hai-ying Shen, J. Coelho, +10 authors J. Chen
- Biology, Medicine
- The Journal of Neuroscience
- 19 March 2008
The function of striatal adenosine A2A receptors (A2ARs) is well recognized because of their high expression levels and the documented antagonistic interaction between A2ARs and dopamine D2 receptors… Expand
Myocardial Infarct–Sparing Effect of Adenosine A2A Receptor Activation Is due to Its Action on CD4+ T Lymphocytes
Background— We previously used adenosine A2A receptor (A2AR) knockout (KO) mice and bone marrow transplantation to show that the infarct-sparing effect of A2AR activation at reperfusion is primarily… Expand
Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms
To investigate whether the motor and neuroprotective effects of adenosine A2A receptor (A2AR) antagonists are mediated by distinct cell types in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine… Expand
Protection from ischemic liver injury by activation of A2A adenosine receptors during reperfusion: inhibition of chemokine induction.
- Y. Day, M. Marshall, L. Huang, M. Mcduffie, M. Okusa, J. Linden
- Medicine, Biology
- American journal of physiology. Gastrointestinal…
- 1 February 2004
Ischemia-reperfusion (I/R) injury occurs as a result of restoring blood flow to previously hypoperfused vessels or after tissue transplantation and is characterized by inflammation and microvascular… Expand
Tumor-derived chemokine CCL5 enhances TGF-β-mediated killing of CD8(+) T cells in colon cancer by T-regulatory cells.
Chemokine CCL5/RANTES is highly expressed in cancer where it contributes to inflammation and malignant progression. In this study, we show that CCL5 plays a critical role in immune escape in… Expand
RANTES mediates kidney ischemia reperfusion injury through a possible role of HIF-1α and LncRNA PRINS
RANTES (Regulated on activation, normal T-cell expressed and secreted), recruits circulating leukocytes and augments inflammatory responses in many clinical conditions. Inflammatory responses in… Expand
A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis.
Adenosine accumulates to high levels in inflamed or ischemic tissues and activates A3 adenosine receptors (ARs) on mast cells to trigger degranulation. Here we show that stimulation of rat basophilic… Expand
Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells.
Activation of A2A adenosine receptors (A2ARs) protects kidneys from ischemia-reperfusion injury (IRI). A2ARs are expressed on bone marrow-derived (BM-derived) cells and renal smooth muscle,… Expand