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spirorenone

Known as: 6 beta, 7 beta, 15 beta, 16 beta-dimethylene-1,4-androstadiene-(17(beta-1')-spiro-5')-perhydrofuran-2',3-dione, Spiro(17H-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2'(5'H)-furan)-3,5'(10H)-dione, 3',4',6,7,8,9,11,12,13,14,15,16,20,21-tetradecahydro-10,13-dimethyl-, (6R-(6alpha,7alpha,8beta,9alpha,10beta,13beta,14alpha,15alpha,16alpha,17beta))- 
National Institutes of Health

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1 relation

Broader (1)

Androstadienes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Pharmacokinetics of the new aldosterone antagonist, spirorenone, in healthy volunteers after single and repeated daily doses
SummaryThe plasma concentrations of spirorenone in two groups of male volunteers have been determined after single and 14 daily… 
1994
1994
Steroidal spirooxetanes. I. Synthesis and antiandrogenic properties of some 17-spirooxetanoandrostanes
A large number of steroidal 17-spirolactones is known at the present time. The widely known antimineralocorticoid preparations… 
1985
1985
Aldosterone antagonists. 1. Synthesis and activities of 6 beta,7 beta:15 beta,16 beta-dimethylene steroidal spirolactones.
Several derivatives of the highly active aldosterone antagonists dihydrospirorenone (2) and spirorenone (3) were synthesized. The… 
1985
1985
Interaction of spirorenone and related compounds with renal mineralocorticoid receptors and with androgen receptors in human prostate cytosol
1984
1984
The renal action of spirorenone and other 6 beta,7 beta; 15 beta,16 beta-dimethylene-17-spirolactones, a new type of steroidal aldosterone antagonists.
The aldosterone antagonistic activity in vivo and the affinity for mineralocorticoid receptors (MCR) in vitro of 3-(17 beta… 
1983
1983
Determination of canrenone, the major metabolite of spironolactone, in plasma and urine by high-performance liquid chromatography.
1982
1982
Isolation and identification of spirorenone metabolites from the monkey (Macaca fascicularis)
1982
1982
Determination of plasma levels of spirorenone, a new aldosterone antagonist, and one of its metabolites by high-performance liquid chromatography.
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