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spirorenone

Known as: 6 beta, 7 beta, 15 beta, 16 beta-dimethylene-1,4-androstadiene-(17(beta-1')-spiro-5')-perhydrofuran-2',3-dione, Spiro(17H-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2'(5'H)-furan)-3,5'(10H)-dione, 3',4',6,7,8,9,11,12,13,14,15,16,20,21-tetradecahydro-10,13-dimethyl-, (6R-(6alpha,7alpha,8beta,9alpha,10beta,13beta,14alpha,15alpha,16alpha,17beta))- 
 
National Institutes of Health

Papers overview

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2005
2005
A large number of steroidal 17-spirolactones is known at the present time. The widely known antimineralocorticoid preparations… Expand
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1986
1986
The ability of a series of 15,16-methylene-spirolactones in comparison to known antimineralocorticoids to inhibit the renal… Expand
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1985
1985
The ability of 11 steroids with varying degrees of progestogenic potency to inhibit the renal actions of aldosterone was tested… Expand
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1985
1985
Several derivatives of the highly active aldosterone antagonists dihydrospirorenone (2) and spirorenone (3) were synthesized. The… Expand
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1984
1984
The aldosterone antagonistic activity in vivo and the affinity for mineralocorticoid receptors (MCR) in vitro of 3-(17 beta… Expand
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1983
1983
SummaryThe plasma concentrations of spirorenone in two groups of male volunteers have been determined after single and 14 daily… Expand
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1983
1983
An assay procedure for measuring plasma and urine levels of canrenone is described. The drug is extracted with n-hexane-toluene… Expand
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1982
1982
The plasma level of spirorenone was determined 3 h after 1, 8, 22 and 46 daily oral administrations of 20 mg/kg to two female and… Expand
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1982
1982
A method for the determination of plasma concentrations of spirorenone, a new aldosterone antagonist, and one of its metabolites… Expand
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