spiradoline
National Institutes of Health
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Sensitization refers to an increase in sensitivity to the effects of a drug and is believed to play a role in the etiology of…
κ Opioid agonists were at one time proposed as candidate pharmacotherapies for cocaine addiction, mainly because of their ability…
The selective kappa-opioid receptor agonist spiradoline mesylate (U62,066E), an arylacetamide, was synthesized with the intention…
Previous research has shown that compounds with mixed κ and μ activity may have utility for the treatment of cocaine abuse and…
The effects of the indirect dopamine receptor agonist cocaine in the striatum on levels of mRNAs of the immediate-early gene c…
1. The mechanism of the diuretic effect of the kappa opioid receptor agonist spiradoline was investigated in 10 healthy male…
Spiradoline (a congener of the kappa opioid agonist, U-50488H) was evaluated for analgesic and related activities in rodents. In…