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sphingomyelin metabolic process

Known as: sphingomyelin metabolism 
The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the… Expand
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics.
OBJECTIVE Metabolic profiling of small molecules offers a snapshot of physiological processes. To identify metabolic signatures… Expand
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Review
2010
Review
2010
Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis.
Sphingolipids in the membranes of neurons play important roles in signal transduction, either by modulating the localization and… Expand
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2010
2010
Increased acid sphingomyelinase activity in peripheral blood cells of acutely intoxicated patients with alcohol dependence.
BACKGROUND Acid sphingomyelinase (ASM; EC 3.1.4.12) hydrolyses membrane sphingomyelin into the bioactive lipid ceramide and is… Expand
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Highly Cited
2005
Highly Cited
2005
Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin
Amyloid beta peptide (Aβ) has a key role in the pathological process of Alzheimer's disease (AD), but the physiological function… Expand
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2002
2002
Unsaturated fatty acid-mediated decreases in sterol regulatory element-mediated gene transcription are linked to cellular sphingolipid metabolism.
A major physiological feedback mechanism of cholesterol in transcription of a number of lipid metabolism-related genes is… Expand
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2002
2002
A fluorescence-based, high-throughput sphingomyelin assay for the analysis of Niemann-Pick disease and other disorders of sphingomyelin metabolism.
Sphingomyelin is an important lipid component of cell membranes and lipoproteins that can be hydrolyzed by sphingomyelinases into… Expand
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Highly Cited
1992
Highly Cited
1992
Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.
We recently demonstrated that sphingosine enhances interleukin-1 beta (IL-1)-mediated prostaglandin E2 (PGE2) production in human… Expand
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Review
1990
Review
1990
An update of the enzymology and regulation of sphingomyelin metabolism.
Sphingomyelin is found in plasma membranes and related organelles (such as endocytic vesicles and lysosomes) of all tissues, as… Expand
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1983
1983
Pathways of sphingomyelin metabolism in cultured fibroblasts from normal and sphingomyelin lipidosis subjects.
The metabolism of endogenous sphingomyelin labeled with 32P or [methyl-3H]choline and of exogenous [choline-methyl-3H], [32P… Expand
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1983
1983
Uptake and metabolism of radioactively labeled sphingomyelin in cultured skin fibroblasts from controls and patients with Niemann-Pick disease and other lysosomal storage diseases.
The metabolism of [stearoyl-1-14C]- and [choline-methyl-14C]sphingomyelin, [stearoyl-1-14C]ceramide-1-phospho-N,N… Expand
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