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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
Reactive oxygen species are required for cell proliferation but can also induce apoptosis. In proliferating cells this paradox is solved by the activation of protein kinase B (PKB; also known as… Expand
Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function.
Gene targeting in mice was used to investigate the unknown function of Scp2, encoding sterol carrier protein-2 (SCP2; a peroxisomal lipid carrier) and sterol carrier protein-x (SCPx; a fusion protein… Expand
Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.
- Andreas Moritz, P. N. de Graan, W. Gispen, K. Wirtz
- Biology, Medicine
- The Journal of biological chemistry
- 15 April 1992
The lipid dependence of phosphatidylinositol-4-phosphate (PIP) kinase purified from bovine brain membranes was investigated. In the assay used, PIP-Triton X-100 micelles containing the lipid to be… Expand
FRET microscopy demonstrates molecular association of non‐specific lipid transfer protein (nsL‐TP) with fatty acid oxidation enzymes in peroxisomes
The fate of fluorescently labeled pre‐nsL‐TP (Cy3‐pre‐nsL‐TP) microinjected into BALB/c 3T3 fibroblasts was investigated by confocal laser scanning microscopy. The protein exhibited a distinct… Expand
Structure of apo‐phosphatidylinositol transfer protein α provides insight into membrane association
- A. Schouten, B. Agianian, J. Westerman, J. Kroon, K. Wirtz, P. Gros
- Medicine, Biology
- The EMBO journal
- 1 May 2002
Phosphatidylinositol transfer protein α (PITPα) is a ubiquitous and highly conserved protein in multicellular eukaryotes that catalyzes the exchange of phospholipids between membranes in vitro and… Expand
Interaction of C-reactive protein with artificial phosphatidylcholine bilayers
C-Reactive protein (CRP), the most characteristic of the ‘acute phase proteins’ (ref. 1) is thought to participate in the mediation and/or modulation of acute inflammatory processes, but its exact… Expand
Phospholipid transfer proteins revisited.
- K. Wirtz
- Biology, Medicine
- The Biochemical journal
- 1 June 1997
Phosphatidylinositol transfer protein (PI-TP) and the non-specific lipid transfer protein (nsL-TP) (identical with sterol carrier protein 2) belong to the large and diverse family of intracellular… Expand
Ratio‐fluorescence microscopy of lipid oxidation in living cells using C11‐BODIPY581/591
A ratio‐fluorescence assay was developed for on‐line localization and quantification of lipid oxidation in living cells. The assay explores the oxidative sensitivity of C11‐BODIPY581/591. Upon… Expand
Peroxisomes in human fibroblasts have a basic pH
eroxisomes are single-membrane-bound organelles found in nearly all eukaryotic cells. These organelles have a central function in lipid metabolism, including the beta-oxidation of verylong-chain and… Expand