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- Publications
- Influence
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
- G. Kops, T. Dansen, +7 authors B. Burgering
- Medicine, Biology
- Nature
- 19 September 2002
Reactive oxygen species are required for cell proliferation but can also induce apoptosis. In proliferating cells this paradox is solved by the activation of protein kinase B (PKB; also known as… Expand
Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function.
- U. Seedorf, M. Raabe, +9 authors G. Assmann
- Medicine, Biology
- Genes & development
- 15 April 1998
Gene targeting in mice was used to investigate the unknown function of Scp2, encoding sterol carrier protein-2 (SCP2; a peroxisomal lipid carrier) and sterol carrier protein-x (SCPx; a fusion protein… Expand
Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.
- Andreas Moritz, P. N. de Graan, W. Gispen, K. Wirtz
- Biology, Medicine
- The Journal of biological chemistry
- 15 April 1992
The lipid dependence of phosphatidylinositol-4-phosphate (PIP) kinase purified from bovine brain membranes was investigated. In the assay used, PIP-Triton X-100 micelles containing the lipid to be… Expand
FRET microscopy demonstrates molecular association of non‐specific lipid transfer protein (nsL‐TP) with fatty acid oxidation enzymes in peroxisomes
- F. Wouters, P. Bastiaens, K. Wirtz, T. Jovin
- Medicine, Biology
- The EMBO journal
- 15 December 1998
The fate of fluorescently labeled pre‐nsL‐TP (Cy3‐pre‐nsL‐TP) microinjected into BALB/c 3T3 fibroblasts was investigated by confocal laser scanning microscopy. The protein exhibited a distinct… Expand
Structure of apo‐phosphatidylinositol transfer protein α provides insight into membrane association
- A. Schouten, B. Agianian, J. Westerman, J. Kroon, K. Wirtz, P. Gros
- Medicine, Biology
- The EMBO journal
- 1 May 2002
Phosphatidylinositol transfer protein α (PITPα) is a ubiquitous and highly conserved protein in multicellular eukaryotes that catalyzes the exchange of phospholipids between membranes in vitro and… Expand
Interaction of C-reactive protein with artificial phosphatidylcholine bilayers
- J. Volanakis, K. Wirtz
- Chemistry, Medicine
- Nature
- 13 September 1979
C-Reactive protein (CRP), the most characteristic of the ‘acute phase proteins’ (ref. 1) is thought to participate in the mediation and/or modulation of acute inflammatory processes, but its exact… Expand
Phospholipid transfer proteins revisited.
- K. Wirtz
- Biology, Medicine
- The Biochemical journal
- 1 June 1997
Phosphatidylinositol transfer protein (PI-TP) and the non-specific lipid transfer protein (nsL-TP) (identical with sterol carrier protein 2) belong to the large and diverse family of intracellular… Expand
Ratio‐fluorescence microscopy of lipid oxidation in living cells using C11‐BODIPY581/591
- E. Pap, G. P. Drummen, +6 authors J. Post
- Chemistry, Medicine
- FEBS letters
- 25 June 1999
A ratio‐fluorescence assay was developed for on‐line localization and quantification of lipid oxidation in living cells. The assay explores the oxidative sensitivity of C11‐BODIPY581/591. Upon… Expand
Peroxisomes in human fibroblasts have a basic pH
- T. Dansen, K. Wirtz, R. Wanders, E. Pap
- Biology, Medicine
- Nature Cell Biology
- 1999
eroxisomes are single-membrane-bound organelles found in nearly all eukaryotic cells. These organelles have a central function in lipid metabolism, including the beta-oxidation of verylong-chain and… Expand