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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
It is shown that the PKB-regulated Forkhead transcription factor FOXO3a (also known as FKHR-L1) protects quiescent cells from oxidative stress by directly increasing their quantities of manganese superoxide dismutase messenger RNA and protein.
Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function.
Gene targeting in mice supported that the gene disruption led to inefficient import of phytanoyl-CoA into peroxisomes and to defective thiolytic cleavage of 3-ketopristanoysl- CoA.
Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.
Interaction of C-reactive protein with artificial phosphatidylcholine bilayers
It is reported here that binding of CRP to model membranes of PC requires the incorporation into the bilayer of lysophosphatidylcholine (LPC), providing a possible biochemical explanation for binding ofCRP to damaged but not intact cell membranes.
FRET microscopy demonstrates molecular association of non‐specific lipid transfer protein (nsL‐TP) with fatty acid oxidation enzymes in peroxisomes
These studies provide strong evidence for a role of nsL‐TP in the regulation of peroxisomal fatty acid β‐oxidation, e.g. by facilitating the presentation of substrates and/or stabilization of the enzymes.
Structure of apo‐phosphatidylinositol transfer protein α provides insight into membrane association
- A. Schouten, B. Agianian, J. Westerman, J. Kroon, K. Wirtz, P. Gros
- Biology, ChemistryThe EMBO journal
- 1 May 2002
The observed open conformer is consistent with a membrane‐bound state of PITP and suggests a mechanism for membrane anchoring and the presentation of phosphatidylinositol to kinases and phospholipases after its extraction from the membrane.
Ratio‐fluorescence microscopy of lipid oxidation in living cells using C11‐BODIPY581/591
Phospholipid transfer proteins revisited.
- K. Wirtz
- Biology, ChemistryThe Biochemical journal
- 1 June 1997
Further studies on these and other known phospholipid transfer proteins are bound to reveal new insights in their important role as mediators between lipid metabolism and cell functions.
Peroxisomes in human fibroblasts have a basic pH
The pH in peroxisomes is studied by targeting a pH-sensitive fluorescent reporter group to these organelles in living fibroblasts by exploiting specific targeting by conjugating the fluorophore to a membrane-permeable peptide that contains a type-Iperoxisome-targeting sequence (PTS1; amino-acid sequence AKL).