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sotatercept

Known as: Decoy Activin Receptor ACE-011 
A soluble fusion protein composed of the extracellular domain of the activin receptor type IIA (ActRIIA) linked to the Fc portion of human IgG1 with… 
National Institutes of Health

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ACE-011

Papers overview

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Review
2019
Review
2019
Myelodysplastic syndrome Transforming growth factor ( TGF )-β pathway as a therapeutic target in lower risk myelodysplastic syndromes
The transforming growth factor (TGF)-β superfamily comprises more than 30 soluble growth factors that play a central role in… 
2019
2019
ACTRIIA-Fc (Sotatercept) Reverses Pulmonary Vascular Remodeling to Attenuate Pulmonary Arterial Hypertension (PAH) by Rebalancing TGF-b/BMP Signaling in a Preclinical Model
Acknowledements Paul B. Yu, M.D., Ph.D. Research Support: Acceleron ActRIIA-Fc reverses pulmonary vascular remodeling, improves… 
Review
2017
Review
2017
Emerging treatment approaches for myeloma-related bone disease
ABSTRACT Introduction: Multiple myeloma is characterized by the presence of osteolytic lesions that leads to devastating skeletal… 
2016
2016
Phase-2 Study of Sotatercept (ACE-011) in Myeloproliferative Neoplasm-Associated Myelofibrosis and Anemia
Introduction: Anemia is common in MPN-associated myelofibrosis (MF), and current therapies (e.g., erythropoiesis stimulating… 
Review
2016
Review
2016
Investigational therapies for renal disease-induced anemia
ABSTRACT Introduction: The main pillars for the treatment of chronic kidney disease (CKD) associated anemia are peptidic… 
Review
2015
Review
2015
The ESA scenario gets complex: from biosimilar epoetins to activin traps.
Recombinant human erythropoietin (rhEpo, epoetin) has proved beneficial in preventing transfusion-dependent anaemia in patients… 
2015
2015
Phase 1 Dose-Escalation Study of Sotatercept (ACE-011) in Combination with Lenalidomide and Dexamethasone in Patients with Relapsed and/or Refractory Multiple Myeloma
Introduction Anemia and bone disease are hallmarks of multiple myeloma (MM). Sotatercept (ACE-011) is a novel, first-in-class… 
2015
2015
Sotatercept Improves Anemia, Vascular Calcification, and Bone Loss in Patients With End-Stage Kidney Disease on Hemodialysis
• In an ongoing study of sotatercept in HD subjects for the correction of anemia, subjects responding to an erythropoietin… 
2014
2014
An Open-Label, Phase 2, Dose-Finding Study of Sotatercept (ACE-011) in Patients with Low or Intermediate-1 (Int-1)-Risk Myelodysplastic Syndromes (MDS) or Non-Proliferative Chronic Myelomonocytic…
Introduction: Anemia, a hallmark of MDS, is challenging to treat, particularly after failure of erythropoiesis-stimulating agents… 
2012
2012
Exposures and Erythropoietic Responses to Sotatercept (ACE-011) in Healthy Volunteers and Cancer Patients: Implications for Mechanism of Action
Abstract 3454 Introduction: Sotatercept (ACE-011), a recombinant fusion protein consisting of the extracellular domain of the… 
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