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Nutritional supplements cross-contaminated and faked with doping substances.
TLDR
Since 2002 new 'designer' steroids such as prostanozol, methasterone, androstatrienedione etc have been offered on the nutritional supplement market and also cross-contamination with these steroids are expected.
Δ6‐Desaturase (FADS2) deficiency unveils the role of ω3‐ and ω6‐polyunsaturated fatty acids
TLDR
It is shown that deletion of Δ6‐fatty acid desaturase (FADS2) gene expression in the mouse abolishes the initial step in the enzymatic cascade of PUFA synthesis, and is anticipated that FADS2 will become a major focus in membrane, haemostasis, inflammation and atherosclerosis research.
Factors influencing the steroid profile in doping control analysis.
TLDR
Pharmaceutical (application of endogenous steroids and various pharmaceutical preparations), technical (hydrolysis, derivatization, matrix), and biological (bacterial activities, enzyme side activities) issues are reviewed.
In vitro phase I metabolism of the synthetic cannabimimetic JWH-018
TLDR
The cytochrome P450 phase I metabolites of JWH-018 were investigated, after in vitro incubation of the drug with human liver microsomes followed by liquid chromatography–tandem mass spectrometry analysis, and evidence of trihydroxylation at different locations of the hydroxyl groups in the molecule was found.
RBC-NOS-Dependent S-Nitrosylation of Cytoskeletal Proteins Improves RBC Deformability
TLDR
This study first-time provides strong evidence that RBC-NOS-produced NO modifies RBC deformability through direct S-nitrosylation of cytoskeleton proteins, most likely α- and β-spectrins.
Selective androgen receptor modulators: in vitro and in vivo metabolism and analysis
TLDR
The analytical UPLC-QqQ-MS/MS procedure was validated for three commercially available arylpropionamides according to European Union criteria, and resulted in decision limits ranging from 0.025 to 0.05 µg l–1 and the linearity was 0.999 for all compounds.
Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases.
TLDR
The high activity of UGT1A8 and 1A10 toward some of the substrates indicates that extrahepatic enzymes might play a role in the metabolism of anabolic androgenic steroids.
Evaluation of commercially available assays for the measurement of equine insulin.
TLDR
To identify an accurate and reliable assay for equine insulin, 6 commercial immunoassays were evaluated for precision, accuracy, and specificity and it was suggested that the Siemens Insulin RIA is appropriate to use for routine evaluations when LC-MS is not available.
Different mechanical loading protocols influence serum cartilage oligomeric matrix protein levels in young healthy humans
TLDR
The elevation of COMP serum concentration seems to depend on the loading mode of the physical activity and to reflect the extrusion of COMP fragments from the impact loaded articular cartilage or synovial fluid.
Long‐term engraftment following transplantation of pig pancreatic primordia into non‐immunosuppressed diabetic rhesus macaques
TLDR
It is shown that beta cells originating from embryonic day (E) 28 (E28) pig pancreatic primordia transplanted into the mesentery of streptozotocin (STZ)‐diabetic (type 1) Lewis rats or Zucker Diabetic Fatty (ZDF) diabetic (type 2) rats engraft and normalize glucose tolerance without the need for host immune‐suppression.
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