sordarin
National Institutes of Health
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Diphthamide is a highly conserved modification of archaeal and eukaryal translation elongation factor 2 (EF2) and yet why cells…
The sordarin family of compounds, characterized by a unique tetracyclic diterpene core including a norbornene system, inhibits…
The sordarins are fungal specific inhibitors of the translation factor eEF2, which catalyzes the translocation of tRNA and mRNA…
We describe a synthesis of ketones 3 (X = O-R or CN; Y = H or alkyl), which are useful building blocks for the preparation of…
ABSTRACT Sordarin derivatives (Glaxo Wellcome) are a new class of compounds that selectively inhibit fungal protein synthesis and…
ABSTRACT Sordarins are a new class of antifungal agents which selectively inhibit fungal protein synthesis (FPS) by impairing the…
ABSTRACT Sordarin derivatives represent a new class of antifungal agents that act as potent inhibitors of fungal protein…
Sordarin derivatives are remarkably selective inhibitors of fungal protein synthesis. Available evidence points to a binding site…