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solanezumab

Known as: Immunoglobulin G1, anti-(human beta-amyloid peptide) (humanized monoclonal LY2062430 heavy chain, disulfide with humanized monoclonal LY2062430 light chain, dimer) 
A humanized monoclonal antibody (IgG1) raised against amyloid beta peptides with Alzheimer disease treatment application. Solanezumab recognizes and… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Antibodies, Monoclonal, Humanized

Narrower (1)

LY 2062430
antigen binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Does Solanezumab Slow Cognitive Decline in Alzheimer Disease
Evidence suggests that the accumulation of amyloid-beta (Aβ) peptides in the brain is an important factor in the pathophysiology… 
2016
2016
UK scientists excited by surprise £2-billion government windfall
Cash to include fund modelled on DARPA, the US defence department’s research arm — but how much will go to basic research is… 
2016
2016
[Immunotherapy for Alzheimer's disease targeting Aβ].
Active and passive immunization of Alzheimer model mice with Aβ showed clearance of aggregated amyloid β deposits and improved… 
2016
2016
Solanezumabの国際共同第III相臨床試験（EXPEDITION1およびEXPEDITION2）：併合解析の日本人集団結果
Solanezumabのアルツハイマー型認知症(AD)に対する有効性と安全性を検討するため,2つの国際共同第Ⅲ相臨床試験を実施した。2試験の結果から軽度AD患者のみを対象に2試験の併合解析を実施し,日本人軽度AD患者(126例)と全軽度AD患者(1,322… 
2016
2016
Featured Article Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients
Introduction: EXPEDITION and EXPEDITION2 were identically designed placebo-controlled phase 3 studies assessing effects of… 
2014
2014
Doug Williams
Doug Williams, head of Research and Development at Biogen Idec, discusses remyelinating agents, Alzheimer's disease drugs and… 
2014
2014
Two Large Alzheimer's Trials Fail to Meet Endpoints: What's Next?
Two anti-amyloid antibody drugs aimed at reducing plaque buildup in Alzheimer’s disease (AD) patients failed to show benefits in… 
2013
2013
Why “Subjective Cognitive Decline” Is Important
We have the target protein for Alzheimer, the antibody to knock out the protein, and the imaging test locating the protein in the… 
2011
2011
シンポジウム32―3 神経疾患に対する抗体療法 アルツハイマー病に対する抗体療法
In order to avoid Abeta-induced autoimmune encephalitis, several monoclonal and polyclonal antibodies are in clinical trials… 
1980
1980
News in brief
The UK Health Protection Agency (HPA) has warned about the need to develop new antibiotics before our current treatment options…