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soblidotin
A dolastatin-10 derivative. Soblidotin inhibits tubulin polymerization, resulting in cell cycle arrest and induction of apoptosis. (NCI04)
National Institutes of Health
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Related topics
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5 relations
Broader (3)
Antineoplastic Agents
Oligopeptides
auristatin PE
Microtubule Process
Narrower (1)
TZT 1027
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2008
2008
Gateways to clinical trials. July-August 2008.
A. Tomillero
,
M. A. Moral
Methods and Findings in Experimental and Clinical…
2008
Corpus ID: 23111308
(-)-Epigallocatechin gallate, 501516, 89-12; Abatacept, Adalimumab, Adefovir dipivoxil, AG-701, Agatolimod sodium, Alefacept…
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2007
2007
A Phase I Study Of The Combination Of TZT-1027 (Soblidotin) And Gemcitabine Administered On Day 1 And 8 Every Three Weeks To Patients With Advanced Or Metastatic Solid Tumors
C. Verschraegen
,
H. Raftopoulos
,
K. Feit
,
R. Jager
,
Sang-Joon Lee
,
C. Sweeney
2007
Corpus ID: 73522299
Background: TZT-1027 is a dolastatin 10 analog interfering with microtubule assembly, with increased antitumor activity when…
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