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sinomenine

Known as: kukoline, morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9alpha,13alpha,14alpha)-, 4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en- 6-one 
An alkaloid isolated from the root of Sinomenium acutum with immunomodulatory and potential anti-angiogenic and activities. Although the mechanism of… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Antirheumatic AgentsMorphinans

Narrower (1)

sinomenine hydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes
Sinomenine is a nonaddictive alkaloid used to prevent morphine dependence, even thoughits mechanism isnot fully understood… 
2012
2012
Therapeutic Effects of Sinomenine Microemulsion-Based Hydrogel on Adjuvant- Induced Arthritis in Rats
Therapeutic Effects of Sinomenine Microemulsion- Based Hydrogel on Adjuvant-Induced Arthritis in Rats Sinomenine is an alkaloid… 
2009
2009
Chitosan-graft poly(p-dioxanone) copolymers: preparation, characterization, and properties.
2009
2009
Effect of sinomenine on the in vitro intestinal epithelial transport of selected compounds
Herbal products can interfere with allopathic medicinal treatment through pharmacokinetic and pharmacodynamic interactions… 
2007
2007
Three major urinary metabolites of sinomenine in rats
Urinary metabolites of sinomenine were investigated in rats after intragastric administration. Three major metabolites were… 
2005
2005
Pharmacokinetic interaction of paeoniflorin and sinomenine: pharmacokinetic parameters and tissue distribution characteristics in rats and protein binding ability in vitro.
The root of Paeonia lactiflora and the stem of Sinomenium acutum are two herbs widely used in Chinese herbal medicine for the… 
1999
1999
Synergistic Effects of the Alkaloid Sinomenine in Combination with the Immunosuppressive Drugs Tacrolimus and Mycophenolic Acid**
Sinomenium acutum in vitro 
1996
1996
Immunomodulatory effects of the alkaloid sinomenine in the high responder ACI-to-Lewis cardiac allograft model.
Extracts of the plant Sinomenium acutum have been used safely since ancient times in Chinese medicine for treatment of rheumatic… 
1985
1985
Effect of sinomenine on antibody responses in mice.
Sinomenine, an epimorphinan alkaloid, was tested for the immunosuppressive effect in mice. This compound produced a decrease of… 
1968
1968
Phenol oxidation and biosynthesis. XVII. Investigations on the biosynthesis of sinomenine.
The biosynthesis of sinomenine in Sinomenium acutum has been investigated. In accordance with phenol coupling theory, reticuline… 
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