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sepiapterin reductase activity

Known as: 7,8-dihydrobiopterin:NADP+ oxidoreductase activity 
Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+. [EC:1.1.1.153]
National Institutes of Health

Papers overview

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Review
2006
Review
2006
Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase.
Tetrahydrobiopterin (BH(4)) deficiencies are a highly heterogeneous group of disorders with several hundred patients, and so far… Expand
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1996
1996
Characterization of sepiapterin reductase activity from Drosophila melanogaster.
A kinetic study of Drosophila melanogaster sepiapterin reductase has been done. The apparent Km for sepiapterin has been… Expand
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1990
1990
Control of tetrahydrobiopterin synthesis in T lymphocytes by synergistic action of interferon-gamma and interleukin-2.
The control of (6R)-5,6,7,8-tetrahydrobiopterin (H4biopterin) synthesis in primed T cells was analyzed by using the human T cell… Expand
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