separase

Known as: Separase [Chemical/Ingredient]

Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin…

National Institutes of Health

Papers overview

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2017

This corrects the article DOI: 10.1038/nature21061

Review

2011

Review

2011

Review on CDC20 (cell division cycle 20 homolog (S. cerevisiae)), with data on DNA, on the protein encoded, and where the gene is…

2007

Although aneuploidy is thought to be the initiator of cancer, the mechanisms leading to aneuploidy remain unclear. To elucidate…

2007

Late mitotic events are chiefly controlled by proteolysis of key regulatory proteins via the ubiquitin-proteasome pathway. In…

2006

During anaphase, the cysteine protease separase cleaves cohesin and releases sister chromatids. In budding yeast, separase also…

2004

The absence of p53 function increases risk for spontaneous tumorigenesis in the mammary gland. Hormonal stimulation enhances…

2003

![Graphic][1] Cohesin rings hold chromatids together until the ring is cleaved at anaphase. Nasmyth New insight into the…

2003

![Graphic][1] Proteins find binding sites by hopping from one site to the next rather than by sliding. Halford/EMBO Arecent…

2003

![Graphic][1] Overhang length drops at senescence (sen) but is rescued by telomerase (TERT). Weinberg/Macmillan Cells with…

2002

Patricia Bilodeau, Robert Piper, and colleagues (University of Iowa, Iowa City, IA) have identified an endosomal receptor complex…