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separase

Known as: Separase [Chemical/Ingredient] 
Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin… 
National Institutes of Health

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AESP protein, ArabidopsisSEP-1 protein, C elegansSse protein, Drosophila
ESPL1 geneIn BloodProcess of secretionantagonists & inhibitors

Papers overview

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2011
2011
Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice
Background Cohesin protease Separase plays a key role in faithful segregation of sister chromatids by cleaving the cohesin… 
2008
2008
Phosphorylation-dependent Binding of Cyclin B1 to a Cdc6-like Domain of Human Separase*
Sister chromatids are held together by the ring-shaped cohesin complex, which likely entraps both DNA-double strands in its… 
2007
2007
Mitotic exit in two dimensions.
2006
2006
Regulation of Separase in Meiosis: Separase is Activated at the Metaphase I-II Transition in Xenopus Oocytes during Meiosis
Separase is a cysteine protease conserved in all eukaryotes and functions to remove the sisterchromatid cohesion in anaphase by… 
2006
2006
Fission Yeast MAP Kinase Is Required for the Increased Securin-Separase Interaction That Rescues Separase Mutants Under Stress
Sister chromatid separation requires two steps of proteolysis. Securin, the chaperon and inhibitor of separase, is destructed in… 
2005
2005
Roles and regulation of the Drosophila centromere cohesion protein MEI-S332 family
In meiosis, a physical attachment, or cohesion, between the centromeres of the sister chromatids is retained until their… 
Highly Cited
2005
Highly Cited
2005
Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells.
The spindle assembly checkpoint monitors the integrity of the spindle microtubules, which attach to sister chromatids at… 
Review
2005
Review
2005
Rephrasing anaphase: separase FEARs shugoshin
Cleavage of the ring-like cohesin complex by separase triggers segregation of sister chromatids in anaphase. This simplistic… 
Highly Cited
2004
Highly Cited
2004
Studies on Substrate Recognition by the Budding Yeast Separase*
Sister chromatid cohesion is resolved at anaphase onset when separase, a site-specific protease, cleaves the Scc1 subunit of the… 
Review
2003
Review
2003
Separase regulation during mitosis.
The final, irreversible step in the duplication and distribution of genomes to daughter cells takes place when chromosomes split… 
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