separase

Known as: Separase [Chemical/Ingredient] 
Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin… (More)
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
It has been proposed that separase-dependent centriole disengagement at anaphase licenses centrosomes for duplication in the next… (More)
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Highly Cited
2008
Highly Cited
2008
Separase is an endopeptidase that separates sister chromatids by cleaving cohesin Rad21 during the metaphase-to-anaphase… (More)
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Highly Cited
2006
Highly Cited
2006
After anaphase, the high mitotic cyclin-dependent kinase (Cdk) activity is downregulated to promote exit from mitosis. To this… (More)
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Highly Cited
2006
Highly Cited
2006
In yeast, resolution of chiasmata in meiosis I requires proteolytic cleavage along chromosome arms of cohesin's Rec8 subunit by… (More)
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Highly Cited
2005
Highly Cited
2005
Stable maintenance of genetic information requires chromosome segregation to occur with high accuracy. Anaphase is triggered when… (More)
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Highly Cited
2003
Highly Cited
2003
Separase is a protease that triggers chromosome segregation at anaphase onset by cleaving cohesin, the chromosomal protein… (More)
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Highly Cited
2003
Highly Cited
2003
Faithful segregation of homologous chromosomes during the first meiotic division is essential for further embryo development. The… (More)
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Highly Cited
2002
Highly Cited
2002
In budding yeast, the phosphatase Cdc14, a key regulator of exit from mitosis, is released from its inhibitor Cfi1/Net1 in the… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister… (More)
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Highly Cited
2001
Highly Cited
2001
Anaphase in budding yeast is triggered by cleavage of the central subunit, Scc1, of the chromosomal cohesin complex by the… (More)
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