selurampanel

INTRODUCTION Epilepsy is a neurological disorder that significantly impacts the quality of life of affected persons. Despite… Expand

ABSTRACT Introduction: Epilepsy is one of the most serious neurological conditions, affecting almost 50 million people around the… Expand

&NA; Poor water solubility of drugs fuels complex formulations and jeopardizes patient access to medication. Simplifying these… Expand

A series of potent quinazolinedione sulfonamide antagonists of the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA… Expand

Topiramate is a new antiepileptic drug (AED) that has been approved worldwide (in more than 80 countries) for the treatment of… Expand

Currently information is available for 20 potential anti-seizure drugs in clinical development. They include candidates with… Expand

OBJECTIVE Examine the efficacy of a competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate glutamate… Expand

INTRODUCTION AMPA-type glutamate receptor (AMPAR) antagonism is under development as a novel mechanism of action for… Expand