selenocysteine biosynthetic process

Known as: selenocysteine anabolism, selenocysteine formation, selenocysteine synthesis 
The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other… (More)
National Institutes of Health

Papers overview

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2010
2010
Mutations disrupting selenocysteine formation cause progressive cerebello-cerebral atrophy.
The essential micronutrient selenium is found in proteins as selenocysteine (Sec), the only genetically encoded amino acid whose… (More)
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2009
2009
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation.
Selenocysteine is the only genetically encoded amino acid in humans whose biosynthesis occurs on its cognate transfer RNA (tRNA… (More)
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Highly Cited
2008
Highly Cited
2008
Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: interaction with sex.
BACKGROUND Selenium is essential for health in humans. Selenium is present as selenocysteine in selenoproteins such as the… (More)
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Highly Cited
2006
Highly Cited
2006
Supramolecular complexes mediate selenocysteine incorporation in vivo.
Selenocysteine incorporation in eukaryotes occurs cotranslationally at UGA codons via the interactions of RNA-protein complexes… (More)
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Highly Cited
2004
Highly Cited
2004
Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function.
Selenium is essential in mammalian embryonic development. However, in adults, selenoprotein levels in several organs including… (More)
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Review
2001
Review
2001
Selenoprotein synthesis in archaea.
The availability of the genome sequences from several archaea has facilitated the identification of the encoded selenoproteins… (More)
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1996
1996
Selenocysteine synthesis in mammalia: an identity switch from tRNA(Ser) to tRNA(Sec).
The mechanism of selenocysteine insertion into proteins is distinct from all other amino acids in all lines of descent in that it… (More)
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1995
1995
Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis.
Selenocysteine is co-translationally incorporated into prokaryotic and eukaryotic selenoproteins at in-frame UGA codons. However… (More)
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Highly Cited
1995
Highly Cited
1995
Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme.
Type 3 iodothyronine deiodinase (D3) catalyzes the conversion of T4 and T3 to inactive metabolites. It is highly expressed in… (More)
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1994
1994
The selenium metabolite selenodiglutathione induces p53 and apoptosis: relevance to the chemopreventive effects of selenium?
Selenodiglutathione (SDG), the initial metabolite of selenite, is shown to be a more powerful inhibitor of cell growth in vitro… (More)
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