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saredutant

National Institutes of Health

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SR 48968

Papers overview

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2013
2013
Behavioural and neurochemical changes induced by stress-related conditions are counteracted by the neurokinin-2 receptor antagonist saredutant.
These experiments were undertaken to assess the mechanisms underlying the antidepressant-like effects of the neurokinin-2 (NK(2… 
2011
2011
Bidirectional regulation of human colonic smooth muscle contractility by tachykinin NK(2) receptors.
In this study, we attempted to clarify the mechanism of tachykinin-induced motor response in isolated smooth muscle preparations… 
2009
2009
The effect of the tachykinin NK2 receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in asthmatics
Objective: We previously reported that the nonpeptide tachykinin NK2 receptor antagonist SR48968 (saredutant) significantly… 
2008
2008
Role of tachykinin NK(1) and NK(2) receptors in colonic sensitivity and stress-induced defecation in gerbils.
2008
2008
Contractile effect of tachykinins on Suncus murinus (house musk shrew) isolated ileum
Highly Cited
2006
Highly Cited
2006
Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils
Review
2000
Review
2000
Neural mechanisms in asthma.
Advances in the understanding of neural mechanisms in asthma may provide novel therapeutic approaches in the treatment of asthma… 
Highly Cited
1998
Highly Cited
1998
The effect of the NK2 tachykinin receptor antagonist SR 48968 (saredutant) on neurokinin A-induced bronchoconstriction in asthmatics.
Inhalation of neurokinin (NK) A causes bronchoconstriction in patients with asthma. The NKA-induced bronchoconstriction in… 
1998
1998
Effects of SR 140333 and SR 48968 on antigen and substance P‐induced activation of guinea‐pig alveolar macrophages
Tachykinins, such as substance P, might be involved in the development of airway hyperresponsiveness and airway inflammation. 
1997
1997
A tachykinin NK3 receptor antagonist, SR 142801 (osanetant), prevents substance P-induced bronchial hyperreactivity in guinea-pigs.
Aerosolized substance P (0.1 M, for 30 min) induced airway hyperresponsiveness in guinea-pigs 24 h after they were pre-treated… 
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