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salvicine

National Institutes of Health

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Naphthoquinones

Papers overview

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2008
2008
The Telomeric Protein TRF2 Is Critical for the Protection of A549 Cells from Both Telomere Erosion and DNA Double-Strand Breaks Driven by Salvicine
Telomere repeat binding factor 2 (TRF2) has been increasingly recognized to be involved in DNA damage response and telomere… 
Review
2007
Review
2007
Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation
AbstractSalvicine is a novel diterpenoid quinone compound obtained by structural modification of a natural product lead isolated… 
2005
2005
Antimetastatic Effect of Salvicine on Human Breast Cancer MDA-MB-435 Orthotopic Xenograft Is Closely Related to Rho-Dependent Pathway
Purpose: Salvicine is a novel DNA topoisomerase II inhibitor with potent anticancer activity. In present study, the effect of… 
2004
2004
Characterization of salvicine‐resistant lung adenocarcinoma A549/SAL cell line
Salvicine is a diterpenoid quinone derived from a traditional Chinese medication that has been shown to possess potent in vitro… 
2003
2003
Actinomycin D inhibiting K562 cell apoptosis elicited by salvicine but not decreasing its cytotoxicity.
AIM To study the effects of actinomycin D (Act D) on the cytotoxicity and apoptosis elicited by salvicine in human leukemia K562… 
2001
2001
Induction of apoptosis in human leukemia K-562 and gastric carcinoma SGC-7901 cells by salvicine, a novel anticancer compound
Salvicine (a novel diterpenoid quinone compound) exhibited a marked antitumor activity on human solid tumor cell lines and BALB/c… 
2001
2001
DNA topoisomerase II as the primary cellular target for salvicine in Saccharomyces cerevisiae.
AIM To identify whether DNA topoisomerase II (Topo II) is the primary cellular target of salvicine in Saccharomyces cerevisiae (S… 
2001
2001
PEGylated polycyanoacrylate nanoparticles as salvicine carriers: synthesis, preparation, and in vitro characterization.
AIM To synthesized poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate) (PEGylated PHDCA) with polyethylene… 
2001
2001
Induction of bulk and c‐myc P2 promoter‐specific DNA damage by an anti‐topoisomerase II agent salvicine is an early event leading to apoptosis in HL‐60 cells
1999
1999
In vitro cytotoxicity of salvicine, a novel diterpenoid quinone.
AIM To study the in vitro cytotoxicity of 4,5-seco-5,10-friedo-abieta-3,4-dihydroxy-5(10),6,8,13-tetraene-11, 12-dione (salvicine… 
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