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saintopin

Known as: 5,12-Naphthacenedione, 1,3,8,10,11-pentahydroxy- 
National Institutes of Health

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1 relation

Broader (1)

Benz(a)Anthracenes

Papers overview

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2012
2012
QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP (QSAR) MODELING OF 2-X-5,8-DIMETHOXY-1,4-NAPHTHOQUINONES AGAINST L1210 CELLS
Quinones are present in many drugs such as anthracyclines, daunorubicin, doxorubicin, mitomycin, mitoxantrones and saintopin… 
2005
2005
Design and Synthesis of Beta- Substitued- Gamma- Methylenefuranones, Related Lignan Analogues and Synthetic Studies Towards Saintopin
2002
2002
Synthetic strategies towards saintopin and its derivatives, pyranonaphthoquinone antibiotics and catalytic organic transformations
1998
1998
Novel selective inhibitors for human topoisomerase I, BM2419-1 and -2 derived from saintopin.
Compounds BM2419-1 and -2 were isolated from a culture broth of a fungus Paecilomyces sp. BM2419. It was shown that these novel… 
1996
1996
Drug-induced down-regulation of topoisomerase I in human epidermoid cancer cells resistant to saintopin and camptothecins.
The anticancer agent saintopin induces DNA cleavage mediated by both topoisomerase (topo) I and topo II in vitro through… 
Highly Cited
1991
Highly Cited
1991
Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus.
Saintopin is an antitumor antibiotic recently discovered in mechanistically oriented screening using purified calf thymus DNA… 
1990
1990
Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces.
DNAtopoisomerases I and II are enzymes that alter DNA conformation through a concerted breaking and rejoining of DNAstrands1… 
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