rubradirin
National Institutes of Health
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Master of your domain: A domain of the bifunctional enzyme RubC1 catalyzes the adenylation of tyrosine. This domain can be…
The biosynthesis of aminocoumarin antibiotics requires two acyladenylate‐forming enzymes: one for the activation of L‐tyrosine as…
The rubradirin biosynthetic gene cluster harbors 58 ORFs within a 105.6-kb sequence, which includes all of the genes responsible…
ORF’s for rubN6 and rubN4 have been annotated as thymidine diphosphate glucose 4-ketoreductase and thymidine diphosphate glucose…
An open reading frame, rub52, has been identified as a gene encoding thymidine diphospho-glucose 2,3-dehydratase by sequence…
Sir: Rubradirin'-" contains a C8H,5NO5* moiety not found in rubradirin B5). We here report that acid hydrolysis of rubradirin…
Sir: Basic hydrolysis of rubradirin','•"' and rubradirin B" affords in addition to the previously described rubransarols A and B5…
The antibiotic rubradirin is structurally related to the ansamycin family of antibiotics. Most members of this group act as…