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roxindole

Known as: roxindol 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

EMD 49980

Broader (2)

IndolesPyridines

Papers overview

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2005
2005
Roxindole, a dopamine autoreceptor agonist, in the treatment of major depression
Roxindole is a potent autoreceptor-“selective” dopamine agonist originally developed for the treatment of schizophrenic syndromes… 
2005
2005
Roxindole, a potential antidepressant I. Effect on the dopamine system
SummaryRoxindole (EMD 49980, 5-hydroxy-3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl(1))-butyl(1)]-indole mesylate), a selective… 
2004
2004
Opioid and monoamine systems mediate the discriminative stimulus of tramadol in rats.
1999
1999
Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors
Abstract Roxindole is a potential antidepressant agent. The present study determined its affinity and agonist efficacy at… 
Highly Cited
1998
Highly Cited
1998
Anxiolytic effects of dopamine receptor ligands: I. Involvement of dopamine autoreceptors.
Highly Cited
1996
Highly Cited
1996
Differential effects of direct and indirect dopamine agonists on eye blink rate in cynomolgus monkeys.
Spontaneous eye blink rate was assessed in cynomolgus monkeys treated intramuscularly with the high-efficacy dopamine (DA… 
1994
1994
Roxindole, a dopamine autoreceptor agonist, in the treatment of positive and negative schizophrenic symptoms.
Twenty schizophrenic inpatients with either predominantly positive or predominantly negative symptoms were treated with the… 
Highly Cited
1993
Highly Cited
1993
Effects of serotonergic drugs in experimental brain ischemia: evidence for a protective role of serotonin in cerebral ischemia
Review
1993
Review
1993
Dopamine autoreceptor agonists in the treatment of schizophrenic disorders
1991
1991
Antipsychotic Efficacy of the Dopaminergic Autoreceptor Agonist EMD 49980 (Roxindol)
EMD 49980 is a dopamine agonist with selective affinity to dopamine autoreceptors. Following pharmacological findings in animal… 
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