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rolapitant

Known as: 1,7-diazaspiro(4.5)decan-2-one, 8-(((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-, (5S,8S)- 
 
National Institutes of Health

Papers overview

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2017
2017
Rolapitant, a selective and long‐acting neurokinin‐1 receptor antagonist, is approved in an oral formulation for the prevention… Expand
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2017
2017
Rolapitant, a selective, long‐acting neurokinin‐1 (NK‐1) receptor antagonist, demonstrated efficacy in preventing chemotherapy… Expand
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2016
2016
Rolapitant, a novel neurokinin‐1 receptor antagonist, provided effective protection against chemotherapy‐induced nausea and… Expand
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2016
2016
PurposeAddition of rolapitant to standard antiemetic therapy improved protection against chemotherapy-induced nausea and vomiting… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Chemotherapy-induced nausea and vomiting is a common side-effect of many antineoplastic regimens and can occur for… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Highly emetogenic chemotherapy induces emesis in almost all patients in the absence of prophylaxis. Guidelines… Expand
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Highly Cited
2015
Highly Cited
2015
PurposeRolapitant is a novel, long-acting neurokinin-1 (NK-1) receptor antagonist. This study evaluated the safety and efficacy… Expand
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2014
2014
e20690 Background: Rolapitant is a potent, highly selective, competitive and long acting NK-1 receptor antagonist in development… Expand
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Highly Cited
2012
Highly Cited
2012
NK1 receptor antagonists have been shown to have a variety of physiological and potential therapeutic effects in animal models… Expand
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2011
2011
BACKGROUND:Postoperative nausea and vomiting (PONV) are common complications after surgery. Neurokinin-1 (NK1) receptor… Expand
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