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rolapitant

Known as: 1,7-diazaspiro(4.5)decan-2-one, 8-(((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-, (5S,8S)- 
National Institutes of Health

Papers overview

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2017
2017
Rolapitant, a selective and long‐acting neurokinin‐1 receptor antagonist, is approved in an oral formulation for the prevention… Expand
Highly Cited
2016
Highly Cited
2016
Rolapitant, a novel neurokinin‐1 receptor antagonist, provided effective protection against chemotherapy‐induced nausea and… Expand
Highly Cited
2015
Highly Cited
2015
BACKGROUND Chemotherapy-induced nausea and vomiting is a common side-effect of many antineoplastic regimens and can occur for… Expand
Highly Cited
2015
Highly Cited
2015
BACKGROUND Highly emetogenic chemotherapy induces emesis in almost all patients in the absence of prophylaxis. Guidelines… Expand
Highly Cited
2015
Highly Cited
2015
PurposeRolapitant is a novel, long-acting neurokinin-1 (NK-1) receptor antagonist. This study evaluated the safety and efficacy… Expand
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Review
2015
Review
2015
The incidence of nausea and vomiting after radiotherapy is often underestimated by physicians, though some 50–80% of patients may… Expand
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Review
2015
Review
2015
The prevention of chemotherapy-induced nausea and vomiting (CINV) has been revolutionized over the past 25 years. Guideline-based… Expand
2014
2014
e20690 Background: Rolapitant is a potent, highly selective, competitive and long acting NK-1 receptor antagonist in development… Expand
Highly Cited
2012
Highly Cited
2012
NK1 receptor antagonists have been shown to have a variety of physiological and potential therapeutic effects in animal models… Expand
Highly Cited
2011
Highly Cited
2011
BACKGROUND:Postoperative nausea and vomiting (PONV) are common complications after surgery. Neurokinin-1 (NK1) receptor… Expand
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