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rogletimide

Known as: 3-PYG, 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione, Pyridoglutethimide 
An orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a… Expand
National Institutes of Health

Papers overview

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Highly Cited
1996
Highly Cited
1996
Abstract Recent investigations of novel aromatase inhibitors have addressed several important questions related to the… Expand
Highly Cited
1992
Highly Cited
1992
The influence of the prototype aromatase inhibitor Aminoglutethimide (AG) and its analogue Rogletimide (RG) on peripheral… Expand
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Review
1992
Review
1992
  • N. Pérez, J. Borja
  • The Journal of international medical research
  • 1992
  • Corpus ID: 41288672
Aminoglutethimide was the first aromatase inhibitor to be used in breast cancer therapy but, since it interacts with the… Expand
Review
1991
Review
1991
  • R. Santen
  • The Journal of Steroid Biochemistry and Molecular…
  • 1991
  • Corpus ID: 12629201
The biological importance of aromatase rests in the concept that this is the rate-limiting enzyme involved in estrogen… Expand
1991
1991
The aromatase inhibitor, 'pyridoglutethimide' (PyG), has been shown previously to suppress serum oestrogen levels in… Expand
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1991
1991
Estrone sulfatase is an important mechanism of local synthesis of biologically active estrogens in human breast cancer. The human… Expand
1990
1990
Inhibitors of the cytochrome P450 enzyme aromatase, which is involved in the biosynthesis of estrogens from androgens, are of… Expand
1990
1990
The inhibitory effects of pyridoglutethimide (3-ethyl-3-(4-pyridyl)piperidine-2,6-dione), an analogue of aminoglutethimide, on… Expand
Review
1990
Review
1990
  • M. Dowsett
  • The Journal of Steroid Biochemistry and Molecular…
  • 1990
  • Corpus ID: 10515012
Numerous aromatase inhibitors are under development for breast cancer treatment. The major aims are to obtain a drug which at its… Expand
1987
1987
3-Ethyl-3-(4-pyridyl)piperidine-2,6-dione (1) is a strong competitive inhibitor of human placental aromatase (Ki = 1.1 microM… Expand