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rogletimide

Known as: 3-PYG, 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione, Pyridoglutethimide 
An orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a… Expand
National Institutes of Health

Papers overview

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2003
2003
A sensitive method for the separation and determination of R(+)- and S(-) enantiomers of pyridoglutehimide in serum by high… Expand
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1996
1996
Abstract Recent investigations of novel aromatase inhibitors have addressed several important questions related to the… Expand
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1992
1992
The influence of the prototype aromatase inhibitor Aminoglutethimide (AG) and its analogue Rogletimide (RG) on peripheral… Expand
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Review
1992
Review
1992
Aminoglutethimide was the first aromatase inhibitor to be used in breast cancer therapy but, since it interacts with the… Expand
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Review
1991
Review
1991
  • Richard Santen
  • The Journal of Steroid Biochemistry and Molecular…
  • 1991
  • Corpus ID: 12629201
The biological importance of aromatase rests in the concept that this is the rate-limiting enzyme involved in estrogen… Expand
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1991
1991
Estrone sulfatase is an important mechanism of local synthesis of biologically active estrogens in human breast cancer. The human… Expand
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Review
1990
Review
1990
  • Mitchell Dowsett
  • The Journal of Steroid Biochemistry and Molecular…
  • 1990
  • Corpus ID: 10515012
Numerous aromatase inhibitors are under development for breast cancer treatment. The major aims are to obtain a drug which at its… Expand
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1990
1990
The inhibitory effects of pyridoglutethimide (3-ethyl-3-(4-pyridyl)piperidine-2,6-dione), an analogue of aminoglutethimide, on… Expand
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1990
1990
Inhibitors of the cytochrome P450 enzyme aromatase, which is involved in the biosynthesis of estrogens from androgens, are of… Expand
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