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rogletimide

Known as: 3-PYG, 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione, Pyridoglutethimide 
An orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a… Expand
National Institutes of Health

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Related topics

2 relations

Broader (1)

Aminoglutethimide
analogs & derivatives

Papers overview

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2003
2003
Stereoselective determination of pyridoglutethimide enantiomers in serum with a chiral cellulose-based high-performance liquid chromatographic column using solid phase extraction and UV detection.
A sensitive method for the separation and determination of R(+)- and S(-) enantiomers of pyridoglutehimide in serum by high… Expand
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1996
1996
Pharmacology of new aromatase inhibitors
Abstract Recent investigations of novel aromatase inhibitors have addressed several important questions related to the… Expand
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1992
1992
The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer.
The influence of the prototype aromatase inhibitor Aminoglutethimide (AG) and its analogue Rogletimide (RG) on peripheral… Expand
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Review
1992
Review
1992
Aromatase Inhibitors: Clinical Pharmacology and Therapeutic Implications in Breast Cancer
Aminoglutethimide was the first aromatase inhibitor to be used in breast cancer therapy but, since it interacts with the… Expand
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Review
1991
Review
1991
Clinical use of aromatase inhibitors in human breast carcinoma
  • Richard Santen
  • The Journal of Steroid Biochemistry and Molecular…
  • 1991
    • Corpus ID: 12629201
The biological importance of aromatase rests in the concept that this is the rate-limiting enzyme involved in estrogen… Expand
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1991
1991
Introduction and summary. International workshop on lead in bone: implications for dosimetry and toxicology.
 
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1991
1991
Inhibition of estrone sulfatase enzyme in human placenta and human breast carcinoma
Estrone sulfatase is an important mechanism of local synthesis of biologically active estrogens in human breast cancer. The human… Expand
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Review
1990
Review
1990
Clinical development of aromatase inhibitors for the treatment of breast and prostate cancer
  • Mitchell Dowsett
  • The Journal of Steroid Biochemistry and Molecular…
  • 1990
    • Corpus ID: 10515012
Numerous aromatase inhibitors are under development for breast cancer treatment. The major aims are to obtain a drug which at its… Expand
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1990
1990
Selective aromatase inhibition by pyridoglutethimide, an analogue of aminoglutethimide.
The inhibitory effects of pyridoglutethimide (3-ethyl-3-(4-pyridyl)piperidine-2,6-dione), an analogue of aminoglutethimide, on… Expand
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1990
1990
Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction…
Inhibitors of the cytochrome P450 enzyme aromatase, which is involved in the biosynthesis of estrogens from androgens, are of… Expand
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