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rogletimide
Known as:
3-PYG
, 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione
, Pyridoglutethimide
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An orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a…
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National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Aminoglutethimide
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
1998
Review
1998
Aromatase inhibitors as potential cancer chemopreventives.
G. Kelloff
,
R. Lubet
,
+6 authors
C. Sigman
Cancer epidemiology, biomarkers & prevention : a…
1998
Corpus ID: 1077561
Epidemiological and experimental evidence strongly supports a role for estrogens in the development and growth of breast tumors…
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Highly Cited
1996
Highly Cited
1996
Pharmacology of new aromatase inhibitors
P. Lønning
1996
Corpus ID: 71422816
Highly Cited
1992
Highly Cited
1992
The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer.
F. MacNeill
,
A. Jones
,
S. Jacobs
,
P. Lønning
,
T. Powles
,
M. Dowsett
British Journal of Cancer
1992
Corpus ID: 11590155
The influence of the prototype aromatase inhibitor Aminoglutethimide (AG) and its analogue Rogletimide (RG) on peripheral…
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1991
1991
Inhibition of estrone sulfatase enzyme in human placenta and human breast carcinoma
T. Evans
,
M. Rowlands
,
M. Jarman
,
R. Coombes
The Journal of Steroid Biochemistry and Molecular…
1991
Corpus ID: 40703688
Review
1991
Review
1991
Clinical use of aromatase inhibitors in human breast carcinoma
R. Santen
The Journal of Steroid Biochemistry and Molecular…
1991
Corpus ID: 12629201
1991
1991
Endocrine, pharmacokinetic and clinical studies of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione ('pyridoglutethimide') in postmenopausal breast cancer patients.
M. Dowsett
,
F. MacNeill
,
+7 authors
R. Coombes
British Journal of Cancer
1991
Corpus ID: 16111463
The aromatase inhibitor, 'pyridoglutethimide' (PyG), has been shown previously to suppress serum oestrogen levels in…
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1990
1990
Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction…
C. Laughton
,
R. McKenna
,
S. Neidle
,
M. Jarman
,
R. Mccague
,
M. Rowlands
Journal of medicinal chemistry
1990
Corpus ID: 1060059
Inhibitors of the cytochrome P450 enzyme aromatase, which is involved in the biosynthesis of estrogens from androgens, are of…
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Review
1990
Review
1990
Clinical development of aromatase inhibitors for the treatment of breast and prostate cancer
M. Dowsett
The Journal of Steroid Biochemistry and Molecular…
1990
Corpus ID: 10515012
1990
1990
Selective aromatase inhibition by pyridoglutethimide, an analogue of aminoglutethimide.
J. Kitawaki
,
T. Yamamoto
,
+4 authors
H. Okada
Acta endocrinologica
1990
Corpus ID: 29565748
The inhibitory effects of pyridoglutethimide (3-ethyl-3-(4-pyridyl)piperidine-2,6-dione), an analogue of aminoglutethimide, on…
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1987
1987
Analogues of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: derivatives with variable 1-alkyl and 3-alkyl substituents.
C. Leung
,
M. Rowlands
,
M. Jarman
,
A. B. Foster
,
L. Griggs
,
D. E. Wilman
Journal of medicinal chemistry
1987
Corpus ID: 7470821
3-Ethyl-3-(4-pyridyl)piperidine-2,6-dione (1) is a strong competitive inhibitor of human placental aromatase (Ki = 1.1 microM…
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