FAQ

rogletimide

Known as: 3-PYG, 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione, Pyridoglutethimide 
An orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2003
02419862003

Related topics

Related topics

1 relation

Broader (1)

Aminoglutethimide

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
rogletimide
Aminoglutethimide

Papers overview

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2004
2004
Chiral resolution of some piperidine 2, 6-dione drugs by high performance liquid chromatography on Kromasil CHI-DMB column.
Kromasil CHI-DMB chiral stationary phase (CSP) is used to resolve some piperidine-2, 6-diones under normal mobile phase mode… (More)
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1992
1992
The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer.
The influence of the prototype aromatase inhibitor Aminoglutethimide (AG) and its analogue Rogletimide (RG) on peripheral… (More)
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1991
1991
Endocrine, pharmacokinetic and clinical studies of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione ('pyridoglutethimide') in postmenopausal breast cancer patients.
The aromatase inhibitor, 'pyridoglutethimide' (PyG), has been shown previously to suppress serum oestrogen levels in… (More)
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1991
1991
Introduction and summary. International workshop on lead in bone: implications for dosimetry and toxicology.
The aromatase inhibitor, 'pyridoglutethimide' (PyG), has been shown previously to suppress serum oestrogen levels in… (More)
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1991
1991
Pharmacokinetics and pharmacodynamics of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione in patients with postmenopausal breast cancer
The pyridylglutarimide 3-ethyl-3-(4-pyridyl)-piperidine-2,6-dione (PyG) is a novel inhibitor of aromatase that was shown to cause… (More)
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Review
1991
Review
1991
Clinical use of aromatase inhibitors in human breast carcinoma.
  • Reinhard Santen
  • The Journal of steroid biochemistry and molecular…
  • 1991
The biological importance of aromatase rests in the concept that this is the rate-limiting enzyme involved in estrogen… (More)
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1991
1991
Antitumor effect of pyridoglutethimide, an aromatase inhibitor, on 7,12-dimethylbenz(a)anthracene-induced mammary tumors of rat.
The antitumor effects of pyridoglutethimide (PG; 3-ethyl-3-(4-pyridyl) piperidine -2, 6-dione), a new analogue of… (More)
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1990
1990
Selective aromatase inhibition by pyridoglutethimide, an analogue of aminoglutethimide.
The inhibitory effects of pyridoglutethimide (3-ethyl-3-(4-pyridyl)piperidine-2,6-dione), an analogue of aminoglutethimide, on… (More)
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1987
1987
Analogues of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: derivatives with variable 1-alkyl and 3-alkyl substituents.
3-Ethyl-3-(4-pyridyl)piperidine-2,6-dione (1) is a strong competitive inhibitor of human placental aromatase (Ki = 1.1 microM… (More)
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1987
1987
Metabolism and pharmacokinetics of the N- and C-n-octyl analogues of pyridoglutethimide [3-ethyl-3-(4-pyridyl)piperidine-2,6-dione]: novel inhibitors of aromatase.
 
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