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rogletimide

Known as: 3-PYG, 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione, Pyridoglutethimide 
An orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a… 
National Institutes of Health

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Broader (1)

Aminoglutethimide
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Aromatase inhibitors — mechanisms for non-steroidal inhibitors
SummaryThe conversion of androgens to estrogens occurs in a variety of cells and tissues, such as ovarian granulosa and… 
2003
2003
Stereoselective determination of pyridoglutethimide enantiomers in serum with a chiral cellulose-based high-performance liquid chromatographic column using solid phase extraction and UV detection.
Review
1993
Review
1993
New endocrine agents for the treatment of breast cancer.
Over the past 6 years we have focused on developing improved drugs for the treatment of human breast cancer. The use of tamoxifen… 
Review
1992
Review
1992
Aromatase Inhibitors: Clinical Pharmacology and Therapeutic Implications in Breast Cancer
Aminoglutethimide was the first aromatase inhibitor to be used in breast cancer therapy but, since it interacts with the… 
1992
1992
Conformational analysis of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (rogletimide) and discovery of potent 5-alkyl derivatives.
Analysis of the proton NMR spectra of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (rogletimide, 1) shows that it exists in solution… 
Review
1991
Review
1991
Clinical use of aromatase inhibitors in human breast carcinoma
1991
1991
Antitumor effect of pyridoglutethimide, an aromatase inhibitor, on 7,12-dimethylbenz(a)anthracene-induced mammary tumors of rat.
The antitumor effects of pyridoglutethimide (PG; 3-ethyl-3-(4-pyridyl) piperidine -2, 6-dione), a new analogue of… 
Review
1990
Review
1990
Clinical development of aromatase inhibitors for the treatment of breast and prostate cancer
1990
1990
Selective aromatase inhibition by pyridoglutethimide, an analogue of aminoglutethimide.
The inhibitory effects of pyridoglutethimide (3-ethyl-3-(4-pyridyl)piperidine-2,6-dione), an analogue of aminoglutethimide, on… 
1987
1987
Metabolism and pharmacokinetics of the N- and C-n-octyl analogues of pyridoglutethimide [3-ethyl-3-(4-pyridyl)piperidine-2,6-dione]: novel inhibitors of aromatase.
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