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rogletimide

Known as: 3-PYG, 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione, Pyridoglutethimide 
An orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Aminoglutethimide
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1998
Review
1998
Aromatase inhibitors as potential cancer chemopreventives.
Epidemiological and experimental evidence strongly supports a role for estrogens in the development and growth of breast tumors… 
Highly Cited
1996
Highly Cited
1996
Pharmacology of new aromatase inhibitors
Highly Cited
1992
Highly Cited
1992
The influence of aminoglutethimide and its analogue rogletimide on peripheral aromatisation in breast cancer.
The influence of the prototype aromatase inhibitor Aminoglutethimide (AG) and its analogue Rogletimide (RG) on peripheral… 
1991
1991
Inhibition of estrone sulfatase enzyme in human placenta and human breast carcinoma
Review
1991
Review
1991
Clinical use of aromatase inhibitors in human breast carcinoma
  • R. Santen
  • The Journal of Steroid Biochemistry and Molecular…
  • 1991
  • Corpus ID: 12629201
1991
1991
Endocrine, pharmacokinetic and clinical studies of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione ('pyridoglutethimide') in postmenopausal breast cancer patients.
The aromatase inhibitor, 'pyridoglutethimide' (PyG), has been shown previously to suppress serum oestrogen levels in… 
1990
1990
Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction…
Inhibitors of the cytochrome P450 enzyme aromatase, which is involved in the biosynthesis of estrogens from androgens, are of… 
Review
1990
Review
1990
Clinical development of aromatase inhibitors for the treatment of breast and prostate cancer
  • M. Dowsett
  • The Journal of Steroid Biochemistry and Molecular…
  • 1990
  • Corpus ID: 10515012
1990
1990
Selective aromatase inhibition by pyridoglutethimide, an analogue of aminoglutethimide.
The inhibitory effects of pyridoglutethimide (3-ethyl-3-(4-pyridyl)piperidine-2,6-dione), an analogue of aminoglutethimide, on… 
1987
1987
Analogues of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: derivatives with variable 1-alkyl and 3-alkyl substituents.
3-Ethyl-3-(4-pyridyl)piperidine-2,6-dione (1) is a strong competitive inhibitor of human placental aromatase (Ki = 1.1 microM… 
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