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robotnikinin

 
National Institutes of Health

Papers overview

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Review
2018
Review
2018
The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a highly conserved evolutionary pathway… Expand
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2017
2017
Erroneous activation of the Hedgehog pathway has been linked to a great amount of cancerous diseases and therefore a large number… Expand
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2016
2016
In this work, the influence of the metal ions present in vertebrate Sonic Hedgehog was assessed by a series of molecular… Expand
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2012
2012
Macrocyclic Hedgehog (Hh) pathway inhibitors have been discovered with improved potency and maximal inhibition relative to the… Expand
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Highly Cited
2012
Highly Cited
2012
Abnormal Hedgehog (Hh) pathway activity has been reported in many cancers, including basal cell carcinomas, medulloblastomas… Expand
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2011
2011
Sonic hedgehog (Shh) plays an important role in the activation of Shh signaling pathway that regulates preservation and rebirth… Expand
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Review
2010
Review
2010
Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper… Expand
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Highly Cited
2009
Highly Cited
2009
Small-molecule inhibition of extracellular proteins that activate membrane receptors has proved to be extremely challenging… Expand
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Highly Cited
2009
Highly Cited
2009
We report the synthesis and biological activity of a library of aminoalcohol-derived macrocycles from which robotnikinin, a… Expand
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