FAQ

ribosomal protein L5, human

Known as: 60S Ribosomal Protein L5, RPL5 protein, human, RPL5 
60S ribosomal protein L5 (297 aa, ~34 kDa) is encoded by the human RPL5 gene. This protein plays a role in both ribosome formation and RNA binding.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2018
0246820022018

Related topics

Related topics

10 relations
Homo sapiensRNA BindingRNA ProcessingRNA-Binding Proteins
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Broader (1)

Ribosomal Proteins

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
ribosomal protein L5, human
Ribosomes
Homo sapiens
Translation Initiation
RNA Binding
RNA Processing

Papers overview

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2015
2015
Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition
Over the past decade, a number of ribosomal proteins (RPs) have been found to have a role in activating the tumor suppressor p53… (More)
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2014
2014
Ribosomal Proteins L5 and L11 Cooperatively Inactivate c-Myc via RNA-induced Silencing Complex
Oncogene MYC is highly expressed in many human cancers and functions as a global regulator of ribosome biogenesis. Previously, we… (More)
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Highly Cited
2013
Highly Cited
2013
The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress
Several proto-oncogenes and tumor suppressors regulate the production of ribosomes. Ribosome biogenesis is a major consumer of… (More)
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Highly Cited
2013
Highly Cited
2013
5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint.
Recently, we demonstrated that RPL5 and RPL11 act in a mutually dependent manner to inhibit Hdm2 and stabilize p53 following… (More)
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2013
2013
Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity.
Humans have evolved elaborate mechanisms to activate p53 in response to insults that lead to cancer, including the binding and… (More)
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2012
2012
Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis.
Members of the β-karyopherin family mediate nuclear import of ribosomal proteins and export of ribosomal subunits, both required… (More)
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2011
2011
RNA content in the nucleolus alters p53 acetylation via MYBBP1A.
A number of external and internal insults disrupt nucleolar structure, and the resulting nucleolar stress stabilizes and… (More)
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2010
2010
Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations.
BACKGROUND Diamond-Blackfan anemia is a rare, pure red blood cell aplasia of childhood due to an intrinsic defect in… (More)
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2009
2009
Identification of mutations in the ribosomal protein L5 (RPL5) and ribosomal protein L11 (RPL11) genes in Czech patients with Diamond-Blackfan anemia.
Diamond-Blackfan anemia (DBA) is a congenital red blood cell aplasia that is usually diagnosed during early infancy. Apart from… (More)
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2004
2004
Transfer of RPS14 and RPL5 from the mitochondrion to the nucleus in grasses.
Gene transfer from the mitochondrion to the nucleus, a process of outstanding importance to the evolution of the eukaryotic cell… (More)
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