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rebeccamycin

Known as: 5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-, 5H-Indolo[2, 3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12, 13-dihydro-12-(4-O-methyl-.beta.-D-glucopyranosyl)-, 5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione,1,11-dichloro-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl) 
An indolocarbazole glycoside antineoplastic antibiotic isolated from the bacterium Saccharothrix aerocolonigenes. Rebeccamycin intercalates into DNA… 
National Institutes of Health

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2 relations

Broader (1)

Carbazoles
NCIt Antineoplastic Agent Terminology

Papers overview

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2009
2009
Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells
PurposeABCG2 overexpression has been linked to resistance to topoisomerase inhibitors, leading us to examine the potential… 
2008
2008
Structure and Mechanism of the Rebeccamycin Sugar 4′-O-Methyltransferase RebM*
The 2.65-Å crystal structure of the rebeccamycin 4′-O-methyltransferase RebM in complex with S-adenosyl-l-homocysteine revealed… 
2008
2008
Synthesis, Biological Evaluation, and Molecular Modeling Studies of Rebeccamycin Analogues Modified in the Carbohydrate Moiety
A new series of indolocarbazole glycosides containing disaccharides were synthesized and their in vitro antiproliferative… 
2003
2003
A Phase II Study of Rebeccamycin Analog NSC 655649 in Patients with Metastatic Colorectal Cancer
The analog, rebeccamycin tartrate salt (NSC 655649, Cancer Therapy Evaluation Program, National Cancer Institute) has broad… 
2003
2003
A phase II study of rebeccamycin analog (NSC-655649) in metastatic renal cell cancer
Objective: Rebeccamycin analog (NSC-655649) is an antibiotic with antitumor properties demonstrated in preclinical and phase I… 
Highly Cited
2003
Highly Cited
2003
Syntheses and antiproliferative activities of 7-azarebeccamycin analogues bearing one 7-azaindole moiety.
Rebeccamycin analogues containing one azaindole unit, with and without a methyl group on the imide nitrogen and with the sugar… 
2002
2002
Phase I clinical and pharmacokinetic study of NSC 655649, a rebeccamycin analogue, given in both single-dose and multiple-dose formats.
PURPOSE NSC 655649 was given in both single- and multiple-dose formats, to characterize maximum tolerated dose (MTD), toxicity… 
2001
2001
Phase I and pharmacokinetic study of NSC 655649, a rebeccamycin analog with topoisomerase inhibitory properties.
PURPOSE To assess the feasibility of administering NSC 655649, a water-soluble, rebeccamycin analog with topoisomerase inhibitory… 
2001
2001
Phase I clinical and pharmacokinetic study of rebeccamycin analog NSC 655649 given daily for five consecutive days.
PURPOSE Rebeccamycin analog (NSC 655649) is active against a variety of both solid and nonsolid tumor cell lines. We performed a… 
1989
1989
Carbon catabolite regulation of rebeccamycin production inSaccharothrix aerocolonigenes
SummaryA new antitumor antibiotic named rebeccamycin was isolated from fermentations of an actinomycete,Saccharothrix… 
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