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pyroglutamyl-peptidase II

Known as: thyroliberin deamidase, thyrotropin-releasing hormone-degrading serum enzyme, TRH pyroglutamyl peptidase II 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

AminopeptidasePyrrolidonecarboxylic Acid
TRHDE geneanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase.
Suppression of TSH release from the hypothyroid thyrotrophs is one of the most rapid effects of 3,3',5'-triiodothyronine (T(3… 
2009
2009
NMDA receptor up-regulates pyroglutamyl peptidase II activity in the rat hippocampus
2007
2007
Stage-specific Modulation of Neprilysin and Aminopeptidase N in the Limbic System During Kindling Progression
Aminopeptidase N (APN) and neprilysin (NEP) inactivate neuropeptides released into the brain extracellular fluid. We previously… 
1998
1998
Multiple Hypothalamic Factors Regulate Pyroglutamyl Peptidase II in Cultures of Adenohypophyseal Cells: Role of the cAMP Pathway
In the adenohypophysis, thyrotrophin‐releasing hormone (TRH) is inactivated by pyroglutamyl peptidase II (PPII), a TRH‐specific… 
1994
1994
Thyrotropin-releasing hormone downregulates pyroglutamyl peptidase II activity in adenohypophyseal cells.
Pyroglutamyl peptidase II (PPII) is a thyrotropin-releasing hormone (TRH) hydrolyzing ectoenzyme with a narrow specificity. In… 
1994
1994
Pyroglutamyl peptidase II activity is not in the processes of bulbospinal TRHergic neurons
1992
1992
Regional distribution of pyroglutamyl peptidase II in rabbit brain, spinal cord, and organs
1990
1990
Thyroid status regulates particulate but not soluble TRH-degrading pyroglutamate aminopeptidase activity in the rat liver.
Rat liver contains two topologically different TRH-degrading pyroglutamate aminopeptidases. The particulate pyroglutamate… 
Highly Cited
1988
Highly Cited
1988
Tissue-specific regulation of pyroglutamate aminopeptidase II activity by thyroid hormones.
Among the enzymes capable of degrading thyrotropin-releasing hormone (TRH) in vitro, two pyroglutamate aminopeptidases (PGA) are… 
Review
1986
Review
1986
Neuropeptide-specific peptidases: does brain contain a specific TRH-degrading enzyme?
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