pyridomycin
National Institutes of Health
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A series of derivatives of the antimycobacterial natural product pyridomycin have been prepared with the C2-side chain attached…
Antimicrobial resistance (AMR) is a global public health threat that warrants urgent attention. However, the multifaceted nature…
Pyridomycin is an antimycobacterial cyclodepsipeptide assembled by a nonribosomal peptide synthetase/polyketide synthase hybrid…
Pyridomycin, a natural product with potent antituberculosis activity, inhibits a major drug target, the InhA enoyl reductase…
Dihydropyridomycins 2 and 3, which lack the characteristic enol ester moiety of the potent antimycobacterial natural product…
Tuberculosis, a global threat to public health, is becoming untreatable due to widespread drug resistance to frontline drugs such…
Pyridomycin is a structurally unique antimycobacterial cyclodepsipeptide containing rare 3-(3-pyridyl)-l-alanine and 2-hydroxy-3…
Structural studies on pyridomycin have been performed by chemical degradation such as ozonolysis and hydrolysis in alkaline and…