Skip to search formSkip to main contentSkip to account menu

pyrazinamide deamidase

Known as: pyrazinamidase 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Amidohydrolases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase
The nicotinamidase/pyrazinamidase (PncA) of Mycobacterium tuberculosis is involved in the activation of the important front‐line… 
Review
2006
Review
2006
The paradox of pyrazinamide: an update on the molecular mechanisms of pyrazinamide resistance in Mycobacteria.
Pyrazinamide (PZA) is an important front line anti-tuberculosis drug because of its sterilizing activity against semi-dormant… 
Highly Cited
2001
Highly Cited
2001
Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii.
Bacterial pyrazinamidase (PZAase)/nicotinamidase converts pyrazinamide (PZA) to ammonia and pyrazinoic acid, which is active… 
Highly Cited
1999
Highly Cited
1999
Mechanisms of pyrazinamide resistance in mycobacteria: importance of lack of uptake in addition to lack of pyrazinamidase activity.
Mycobacteria are known to acquire resistance to the antituberculous drug pyrazinamide (PZA) through mutations in the gene… 
Highly Cited
1999
Highly Cited
1999
Relationship between Pyrazinamide Resistance, Loss of Pyrazinamidase Activity, and Mutations in the pncA Locus in Multidrug-Resistant Clinical Isolates of Mycobacterium tuberculosis
ABSTRACT Sixty-two Mycobacterium tuberculosis isolates were tested for pyrazinamidase activity, and their pyrazinamide… 
Highly Cited
1997
Highly Cited
1997
Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms
A gene (pncA) with mutations associated with pyrazinamide resistance in Mycobacterium tuberculosis complex members was… 
Highly Cited
1996
Highly Cited
1996
Isolation and characterization of a unique group of slowly growing mycobacteria: description of Mycobacterium lentiflavum sp. nov
A distinct group of slowly growing mycobacteria was identified on the basis of growth characteristics, biochemical and lipid… 
Highly Cited
1993
Highly Cited
1993
Mycobacterium intermedium sp. nov.
Strains of a new type of slowly growing mycobacterium were repeatedly isolated from sputum from a patient with pulmonary disease… 
Highly Cited
1985
Highly Cited
1985
Pyrazinamidase activity in Yersinia enterocolitica and related organisms
Pyrazinamidase activity was tested in 381 Yersinia strains from various ecological and geographical origins and belonging to the… 
Highly Cited
1974
Highly Cited
1974
Simple pyrazinamidase and urease tests for routine identification of mycobacteria.
A specific assay for free pyrazinoic acid has been applied to a study of pyrazinamidase activity of mycobacteria. Evidence is… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)