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purvalanol A

 
National Institutes of Health

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2017
2017
Purvalanol A is a highly selective inhibitor of Cdc2 [also known as cyclin-dependent kinase 1 (CDK1)]. Taxol is an anti-tumor… Expand
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2013
2013
Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their… Expand
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2012
2012
Inhibition of cyclin-dependent kinases by specific small molecules, purine cyclin-dependent kinase inhibitors (CDKi), has become… Expand
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2012
2012
Although preconditioning injury on the peripheral nerve induces axonal regenerative capacity in neurons, it is not known whether… Expand
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2010
2010
The nonreceptor tyrosine kinase c-Src is frequently over-expressed or hyperactivated in various human cancers and contributes to… Expand
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2008
2008
Human T-cell leukemia virus type-1 (HTLV-1) induces adult T-cell leukemia/lymphoma (ATL/L), a fatal lymphoproliferative disorder… Expand
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2008
2008
To clarify the mechanisms of purvalanol A in the induction of apoptosis, we investigated whether purvalanol A influenced the RNA… Expand
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2007
2007
Abstract Iizuka, D., Inanami, O., Kashiwakura, I. and Kuwabara, M. Purvalanol A Enhances Cell Killing by Inhibiting Up-Regulation… Expand
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2005
2005
Cyclin-dependent kinases (CDK) play a crucial role in the control of the cell cycle. Aberrations in the control of cell cycle… Expand
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Highly Cited
2002
Highly Cited
2002
We have studied the effects of purvalanol A on the cell cycle progression, proliferation and viability. In synchronized cells… Expand
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