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purvalanol A

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The Cdc 2 / Cdk 1 inhibitor , purvalanol A , enhances the cytotoxic effects of taxol through Op 18 / stathmin in non-small cell lung cancer cells in vitro
Purvalanol A is a highly selective inhibitor of Cdc2 [also known as cyclin-dependent kinase 1 (CDK1)]. Taxol is an anti-tumor… 
2016
2016
Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs)
Abstract 1. Purine cyclin-dependent kinase inhibitors have recently been recognised as promising candidates for the treatment of… 
2015
2015
Effects of Purvalanol A on Imatinib-Sensitive and -Insensitive Chronic Myeloid Leukaemia Cell Lines
Objectives: This project aimed to investigate effects of purvalanol A on imatinib-sensitive and -insensitive chronic myeloid… 
2014
2014
Abstract 1326: Regulation of AKT phosphorylation by a CDK inhibitor purvalanol A in breast cancer cells
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Akt is a serine/threonine kinase and an essential… 
2013
2013
Purvalanol A, Olomoucine II and Roscovitine Inhibit ABCB1 Transporter and Synergistically Potentiate Cytotoxic Effects of Daunorubicin In Vitro
Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their… 
2010
2010
Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src
2009
2009
Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu mice.
2005
2005
Purvalanol A, inhibitor of cyclin-dependent kinases attenuates proliferation of cells in the dentate gyrus of the adult rat hippocampus.
Several recent findings indicate that intensity of neurogenesis in adult brain might be regulated by enzymes involved in the cell… 
Highly Cited
2004
Highly Cited
2004
Down-regulation of Survivin in Nitric Oxide-induced Cell Growth Inhibition and Apoptosis of the Human Lung Carcinoma Cells*
Survivin is expressed in most tumor cells and has been associated with both anti-apoptosis and mitotic progression. However, the… 
2003
2003
Inhibition of Cdc2 kinase activity by Purvalanol A sensitizes X rays-induced apoptosis in gastric tumor cells
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