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Genetic Analysis of Varicella-Zoster Virus ORF0 to ORF4 by Use of a Novel Luciferase Bacterial Artificial Chromosome System
ABSTRACT To efficiently generate varicella-zoster virus (VZV) mutants, we inserted a bacterial artificial chromosome (BAC) vector in the pOka genome. We showed that the recombinant VZV (VZVBAC)Expand
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Acute Response of Urinary N‐Acetyl-Beta‐D-Glucosaminidase to Mannitol Infusion in the Dog
Urinary activity of N-acetyl-beta-D-glucosaminidase (NAG) has been used as an indicator of subtle renal injury in a variety of conditions. Such enzyme activity has been shown to be increased in humanExpand
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Molecular genetic studies on the mode of action of azole antifungal agents.
Cytochrome P-450 catalysing the 14ademethylation of sterol is inhibited in fungi by azole antifungal compounds resulting in a fungistatic or a fungicidal effect [ 11. The azoles themselves representExpand
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Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu mice.
Varicella-zoster virus (VZV) replicates in quiescent T cells, neurons, and skin cells. In cultured fibroblasts (HFFs), VZV induces host cyclin expression and cyclin-dependent kinase (CDK) activityExpand
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Peptide mapping of 125I-labelled influenza virus proteins. Matrix proteins as markers in recombination.
We have examined the matrix proteins of A/Okuda/57, A/Finland/4/74 and A/New Jersey/8/76 viruses and several recombinant strains by radioiodination of the purified polypeptides followed by trypticExpand
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Study of the electrostatic effects of mutations on the surface of dehaloperoxidase-hemoglobin A.
Point mutations of dehaloperoxidase-hemoglobin A (DHP A) that affect the surface charge have been prepared to study the interaction between DHP A with its substrate 2,4,6-trichlorophenol (TCP).Expand
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Sterol 14α-Demethylase: Target of the Azole Antifungal Agents
The development of inhibitors of sterol C 14 demethylase in fungi has provided a rich source of drugs and pesticides. These compounds have been found to be potent inhibitors of a wide variety ofExpand
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Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity
Combination antiretroviral therapy is the mainstay of HIV treatment, lowering plasma viral levels below detection. However, eradication of HIV is a major challenge due to cellular and anatomicalExpand
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Differential response of urinary N-acetyl-beta-D-glucosaminidase to two osmotic diuretics in the dog.
Urinary N-acetyl-beta-D-glucosaminidase (NAG), a lysosomal hydrolase located the proximal tubule of the kidney, has been used as a marker for subtle renal injury. In humans and other animals withExpand
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