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pteridine reductase activity

Known as: 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity, PTR1, ptr1 activity 
Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 H(+) + 2 NADPH. [EC:1.5.1.33, RHEA:19512]
National Institutes of Health

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1 relation
dihydrobiopterin reduction

Papers overview

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2015
2015
Planejamento e avaliação de novos inibidores de Pteridina Redutase 1 (PTR1) de Leishmania major
A leishmaniose tem sido indicada pela OMS como a segunda protozoose mais importante em termos de mortalidade e prevalencia… 
2013
2013
Biochemical effects of riluzole on Leishmania parasites.
2012
2012
Inhibition of Leishmania major PTR1 Gene Expression by Antisense in Escherichia coli
Background: Protozoa related to Trypanosome family including Leishmania, synthesize enzymes to escape from drug therapy. One of… 
Highly Cited
2010
Highly Cited
2010
Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice
Gene knockout and knockdown methods were used to examine essentiality of pteridine reductase (PTR1) in pterin metabolism in the… 
2008
2008
Molecular Cloning and Expression of Iranian Leishmania major Pteridine Reductase 1
Leishmaniasis is an endemic disease in 88 countries. Reports on Leishmania drug resistance are growing in number. The mechanism… 
2004
2004
Inactivation of the Leishmania tarentolae Pterin Transporter (BT1) and Reductase (PTR1) Genes Leads to Viable Parasites with Changes in Folate Metabolism and Hypersensitivity to the Antifolate…
The protozoan parasite Leishmania is a folate and pterin auxotroph. The main biopterin transporter (BT1) and pterin reductase… 
2002
2002
Characterization of quinonoid-Dihydropteridine Reductase (QDPR) from the Lower Eukaryote Leishmania major *
Biopterin is required for growth of the protozoan parasite Leishmania and is salvaged from the host through the activities of a… 
1999
1999
Mutant PTR1 proteins from Leishmania tarentolae: comparative kinetic properties and active-site labeling.
PTR1, the gene promoting MTX resistance following gene amplification or DNA transfection in Leishmania tarentolae and selected… 
1998
1998
Residues involved in co-factor and substrate binding of the short-chain dehydrogenase/reductase PTR1 producing methotrexate resistance in Leishmania.
The Leishmania short-chain dehydrogenase/reductase gene ptr1 has been isolated while characterizing antifolate-resistant… 
1997
1997
Biochemical and Genetic Tests for Inhibitors of Leishmania Pteridine Pathways
The study of antifolate-resistant mutants of the protozoan parasite Leishmania has provided useful information about genetic… 
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