proto-oncogene protein c-crk
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Shigella, the causative agent of bacillary dysentery, invades epithelial cells in a process involving Src tyrosine kinase… Expand Induction of epithelial cell motility is a fundamental morphogenetic event that is recapitulated during carcinoma metastasis… Expand Pseudomonas aeruginosa ExoT is a type III cytotoxin that functions as an anti-internalization factor with an N-terminal RhoGAP… Expand c-Jun N-terminal kinases (JNKs) are potently activated by a number of cellular stimuli. Small GTPases, in particular Rac, are… Expand The Crk proto-oncogene product is an SH2 and SH3 domain-containing adaptor protein which we have previously shown to become… Expand The Src homology 2 (SH2) domain of the mammalian adaptor protein Crk-II contains a proline-rich insert, predicted to lie within… Expand p47v‐crk (v‐Crk), a transforming gene product containing Src homology (SH)‐2 and ‐3 domains, induces an elevated level of… Expand c‐Crk is a proto‐oncogene product composed largely of Src homology (SH) 2 and 3 domains. We have identified a kinase activity… Expand Two distinct human CRK cDNAs, designated CRK-I and CRK-II, were isolated from human embryonic lung cells by polymerase chain… Expand Although the oncogene product of CT10 virus, P47gag-crk, does not itself phosphorylate proteins at tyrosine residues, it elevates… Expand