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proto-oncogene protein c-crk

Known as: CT10 Regulator of Kinase Protein, c-crk, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-crk [Chemical/Ingredient] 
Signal transducing adaptor proteins that contain SRC HOMOLOGY DOMAINS and play a role in CYTOSKELETON reorganization. c-crk protein is closely… 
National Institutes of Health

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11 relations

Narrower (3)

CRK protein, humanProto-Oncogene Protein c-crk-2Proto-Oncogene Protein c-crk-3
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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Highly Cited
2004
Highly Cited
2004
Activation of Rac1 by Paxillin-Crk-DOCK180 Signaling Complex Is Antagonized by Rap1 in Migrating NBT-II Cells*
Induction of epithelial cell motility is a fundamental morphogenetic event that is recapitulated during carcinoma metastasis… 
Highly Cited
2004
Highly Cited
2004
Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells
Shigella, the causative agent of bacillary dysentery, invades epithelial cells in a process involving Src tyrosine kinase… 
Highly Cited
2003
Highly Cited
2003
Pseudomonas aeruginosa ExoT ADP-ribosylates CT10 Regulator of Kinase (Crk) Proteins*
Pseudomonas aeruginosa ExoT is a type III cytotoxin that functions as an anti-internalization factor with an N-terminal RhoGAP… 
Highly Cited
1998
Highly Cited
1998
The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway.
c-Jun N-terminal kinases (JNKs) are potently activated by a number of cellular stimuli. Small GTPases, in particular Rac, are… 
Highly Cited
1996
Highly Cited
1996
The Proto-oncogene Product c-Crk Associates with Insulin Receptor Substrate-1 and 4PS
The Crk proto-oncogene product is an SH2 and SH3 domain-containing adaptor protein which we have previously shown to become… 
1996
1996
A Potential SH3 Domain-binding Site in the Crk SH2 Domain*
The Src homology 2 (SH2) domain of the mammalian adaptor protein Crk-II contains a proline-rich insert, predicted to lie within… 
Highly Cited
1994
Highly Cited
1994
A novel signaling molecule, p130, forms stable complexes in vivo with v‐Crk and v‐Src in a tyrosine phosphorylation‐dependent manner.
p47v‐crk (v‐Crk), a transforming gene product containing Src homology (SH)‐2 and ‐3 domains, induces an elevated level of… 
Highly Cited
1994
Highly Cited
1994
c‐Abl kinase regulates the protein binding activity of c‐Crk.
c‐Crk is a proto‐oncogene product composed largely of Src homology (SH) 2 and 3 domains. We have identified a kinase activity… 
Highly Cited
1992
Highly Cited
1992
Two species of human CRK cDNA encode proteins with distinct biological activities
Two distinct human CRK cDNAs, designated CRK-I and CRK-II, were isolated from human embryonic lung cells by polymerase chain… 
Highly Cited
1990
Highly Cited
1990
Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins.
Although the oncogene product of CT10 virus, P47gag-crk, does not itself phosphorylate proteins at tyrosine residues, it elevates… 
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