protein kinase activity

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1969-2017
05010019692017

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Highly Cited
2012
Highly Cited
2012
Pyruvate kinase isoform M2 (PKM2) is a glycolysis enzyme catalyzing conversion of phosphoenolpyruvate (PEP) to pyruvate by… (More)
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Highly Cited
2002
Highly Cited
2002
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic glucose production and… (More)
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Highly Cited
2000
Highly Cited
2000
The 5'AMP-activated protein kinase (AMPK) is stimulated by contractile activity in rat skeletal muscle. AMPK has emerged as an… (More)
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Highly Cited
1998
Highly Cited
1998
The p53 tumor suppressor protein is activated and phosphorylated on serine-15 in response to various DNA damaging agents. The… (More)
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Highly Cited
1998
Highly Cited
1998
The present study identifies the operation of a signal tranduction pathway in mammalian cells that provides a checkpoint control… (More)
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Highly Cited
1998
Highly Cited
1998
A constitutively active form of mitogen-activated protein kinase kinase (MEK1) was synthesized under control of a zinc-inducible… (More)
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Highly Cited
1996
Highly Cited
1996
The JNK protein kinase is a member of the MAP kinase group that is activated in response to dual phosphorylation on threonine and… (More)
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Highly Cited
1994
Highly Cited
1994
Using a yeast interaction screen to search for proteins that interact with cyclin D1-Cdk4, we identified a 27 kDa mouse protein… (More)
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Highly Cited
1988
Highly Cited
1988
Long-term potentiation (LTP) of synaptic transmission in the hippocampus is a much-studied example of synaptic plasticity… (More)
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Highly Cited
1978
Highly Cited
1978
Incorporation of phosphorus from [gamma-32P]ATP into protein was catalyzed by specific immunoprecipitates from avian sarcoma… (More)
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